Transplantation for Cholangiocarcinoma

Howard C. Masuoka, Charles B. Rosen

Research output: Contribution to journalReview article

11 Scopus citations

Abstract

Cholangiocarcinoma (CCA) is a primary hepatic neoplasm that arises from malignant transformation of the biliary epithelium. Chronic biliary tree inflammation as occurs in primary sclerosing cholangitis (PSC) is a risk factor for the development of CCA. Surgical resection and liver transplantation following neoadjuvant therapy in patients with early extrahepatic CCA are the only potentially curative modalities. Biliary stenting, chemotherapy, radiation therapy, and photodynamic therapy are palliative treatment options for patients who are not surgical candidates. Liver transplantation following neoadjuvant therapy is an effective therapy for patients with hilar cholangiocarcinoma that is unresectable or arising in the setting of PSC.

Original languageEnglish (US)
Pages (from-to)699-715
Number of pages17
JournalClinics in liver disease
Volume15
Issue number4
DOIs
StatePublished - Nov 1 2011

Keywords

  • Acute cholangitis
  • Biliary stenting
  • Biliary stricture
  • Cholangiocarcinoma
  • Klatskin tumor
  • Liver transplantation
  • Living donor liver transplantation
  • Neoadjuvant therapy

ASJC Scopus subject areas

  • Hepatology

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