Transplant glomerulopathy: Subclinical incidence and association with alloantibody

J. M. Gloor, Sanjeev M Sethi, Mark D Stegall, W. D. Park, S. B. Moore, S. DeGoey, M. D. Griffin, T. S. Larson, Fernando G Cosio

Research output: Contribution to journalArticle

261 Citations (Scopus)

Abstract

Transplant glomerulopathy (TG) usually has been described as part of a constellation of late chronic histologic abnormalities associated with proteinuria and declining function. The current study used both protocol and clinically-indicated biopsies to investigate clinical and subclinical TG, their prognosis and possible association with alloantibody. We retrospectively studied 582 renal transplants with a negative pre-transplant T-cell complement dependent cytotoxicity crossmatch. TG was diagnosed in 55 patients, 27 (49%) based on protocol biopsy in well-functioning grafts. The cumulative incidence of TG increased over time to 20% at 5 years. The prognosis of subclinical TG was equally as poor as TG diagnosed with graft dysfunction, with progressive worsening of histopathologic changes and function. Although TG was associated with both acute and chronic histologic abnormalities, 14.5% of TG biopsies showed no interstitial fibrosis or tubular atrophy, while 58% (7/12) of biopsies with severe TG showed only minimal abnormalities. TG was associated with acute rejection, pretransplant hepatitis C antibody positivity and anti-HLA antibodies (especially anti-Class II), with the risk increasing if the antibodies were donor specific. We suggest that subclinical TG is an under-recognized cause of antibody-mediated, chronic renal allograft injury which may be mechanistically distinct from other causes of nephropathy.

Original languageEnglish (US)
Pages (from-to)2124-2132
Number of pages9
JournalAmerican Journal of Transplantation
Volume7
Issue number9
DOIs
StatePublished - Sep 2007

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Isoantibodies
Transplants
Incidence
Biopsy
Kidney
Hepatitis C Antibodies
Antibodies
Proteinuria

Keywords

  • Alloantibodies
  • Chronic allograft nephropathy (CAN)
  • Chronic transplant glomerulopathy
  • Humoral rejection
  • Protocol biopsies
  • Transplant glomerulopathy

ASJC Scopus subject areas

  • Immunology

Cite this

Transplant glomerulopathy : Subclinical incidence and association with alloantibody. / Gloor, J. M.; Sethi, Sanjeev M; Stegall, Mark D; Park, W. D.; Moore, S. B.; DeGoey, S.; Griffin, M. D.; Larson, T. S.; Cosio, Fernando G.

In: American Journal of Transplantation, Vol. 7, No. 9, 09.2007, p. 2124-2132.

Research output: Contribution to journalArticle

Gloor, J. M. ; Sethi, Sanjeev M ; Stegall, Mark D ; Park, W. D. ; Moore, S. B. ; DeGoey, S. ; Griffin, M. D. ; Larson, T. S. ; Cosio, Fernando G. / Transplant glomerulopathy : Subclinical incidence and association with alloantibody. In: American Journal of Transplantation. 2007 ; Vol. 7, No. 9. pp. 2124-2132.
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