Transplant center characteristics and survival after allogeneic hematopoietic cell transplantation in adults

Navneet S. Majhail, Lih Wen Mau, Pintip Chitphakdithai, Ellen M. Denzen, Steven Joffe, Stephanie J. Lee, Charles F. LeMaistre, Fausto Loberiza, Susan K. Parsons, Ramona Repaczki-Jones, Pam Robinett, J. Douglas Rizzo, Elizabeth Murphy, Brent Logan, Jennifer Le-Rademacher

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Allogeneic hematopoietic cell transplantation (alloHCT) is a highly specialized procedure. We surveyed adult transplant centers in the United States (US) and then used data reported to the Center for International Blood and Marrow Transplant Research (CIBMTR) (2008–2010) to evaluate associations of center volume, infrastructure, and care delivery models with survival post alloHCT. Based on their 2010 alloHCT volume, centers were categorized as low-volume (≤40 alloHCTs; N = 42 centers, 1900 recipients) or high-volume (>40 alloHCTs; N = 41 centers, 9637 recipients). 100-day survival was 86% (95% CI, 85–87%) in high-volume compared with 83% (95% CI, 81–85%) in low-volume centers (difference 3%; P < 0.001). One-year survival was 62% (95% CI, 61–63%) and 56% (95% CI, 54–58%), respectively (difference 6%; P < 0.001). Logistic regression analyses adjusted for patient and center characteristics; alloHCT at high-volume centers (odds ratio [OR] 1.32; P < 0.001) and presence of a survivorship program dedicated to HCT recipients (OR 1.23; P = 0.009) were associated with favorable 1-year survival compared to low-volume centers. Similar findings were observed in a CIBMTR validation cohort (2012–2014); high-volume centers had better 1-year survival (OR 1.24, P < 0.001). Among US adult transplant centers, alloHCT at high-volume centers and at centers with survivorship programs is associated with higher 1-year survival.

Original languageEnglish (US)
Pages (from-to)906-917
Number of pages12
JournalBone Marrow Transplantation
Volume55
Issue number5
DOIs
StatePublished - May 1 2020

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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    Majhail, N. S., Mau, L. W., Chitphakdithai, P., Denzen, E. M., Joffe, S., Lee, S. J., LeMaistre, C. F., Loberiza, F., Parsons, S. K., Repaczki-Jones, R., Robinett, P., Douglas Rizzo, J., Murphy, E., Logan, B., & Le-Rademacher, J. (2020). Transplant center characteristics and survival after allogeneic hematopoietic cell transplantation in adults. Bone Marrow Transplantation, 55(5), 906-917. https://doi.org/10.1038/s41409-019-0748-1