Transmission electron microscopy on a case of Cyclospora cayetanensis infection from an immune-competent case confirms and extends prior detailed descriptions of its notably small endogenous stage

Jitender P. Dubey, Jon E. Charlesworth, Bobbi S. Pritt

Research output: Contribution to journalArticlepeer-review

Abstract

Although infections with Cyclospora cayetanensis are prevalent worldwide, many aspects of this parasite's life cycle remain unknown. Humans are the only known hosts, existing information on its endogenous development has been derived from histological examination of only a few biopsy specimens. In histological sections, its stages are less than 10 μ m, making definitive identification difficult. Here, confirmation of cyclosporiasis in a duodenal biopsy specimen from an 80-year-old man without any recognized immunodeficiency patient is reported. Asexual forms (schizonts) and sexual forms (gamonts) were located within enterocytes, including immature and mature schizonts, an immature male gamont, and a female gamont. Merozoites were small (< 5 μ m × 1 um) and contained two rhoptries, subterminal nucleus, and numerous micronemes and amylopectin granules. These parasite stages were like those recently reported in the gallbladder of an immunocompromised patient, suggesting that the general life cycle stages are not altered by immunosuppression.

Original languageEnglish (US)
JournalParasitology
DOIs
StateAccepted/In press - 2022

Keywords

  • Cyclospora cayetanensis
  • Electron microscopy
  • Humans
  • Life cycle

ASJC Scopus subject areas

  • Parasitology
  • Animal Science and Zoology
  • Infectious Diseases

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