Translocation(X;Y)(p22.33;p11.2) in XX males: Etiology of male phenotype

R. E. Magenis, M. J. Webb, R. S. McKean, D. Tomar, L. J. Allen, H. Kammer, D. L. Van Dyke, E. Lovrien

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Abstract

Analysis of G-banded prometaphase chromosomes from three XX males revealed extra bands on the distal end of one X short arm. These bands were similar both in size and staining properties to the distal Y short arm of their fathers (in the two cases examined) and also to other chromosomally normal males. The extra material on the abnormal X chromosomes was not C-or G-11 positive in the two cases examined, suggesting that the proximal Y long arm was not present. Previous karyotype-phenotype correlations with structurally altered Y chromosomes provided evidence for localization of male determinants on the Y short arm. The present findings in XX males provide support for more precise localization, to bands p11.2→pter of Y short arm.

Original languageEnglish (US)
Pages (from-to)271-276
Number of pages6
JournalHuman genetics
Volume62
Issue number3
DOIs
StatePublished - Dec 1 1982

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ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Magenis, R. E., Webb, M. J., McKean, R. S., Tomar, D., Allen, L. J., Kammer, H., Van Dyke, D. L., & Lovrien, E. (1982). Translocation(X;Y)(p22.33;p11.2) in XX males: Etiology of male phenotype. Human genetics, 62(3), 271-276. https://doi.org/10.1007/BF00333535