Translocation(X;Y)(p22.33;p11.2) in XX males

Etiology of male phenotype

R. E. Magenis, M. J. Webb, R. S. McKean, D. Tomar, L. J. Allen, H. Kammer, D. L. Van Dyke, E. Lovrien

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Analysis of G-banded prometaphase chromosomes from three XX males revealed extra bands on the distal end of one X short arm. These bands were similar both in size and staining properties to the distal Y short arm of their fathers (in the two cases examined) and also to other chromosomally normal males. The extra material on the abnormal X chromosomes was not C-or G-11 positive in the two cases examined, suggesting that the proximal Y long arm was not present. Previous karyotype-phenotype correlations with structurally altered Y chromosomes provided evidence for localization of male determinants on the Y short arm. The present findings in XX males provide support for more precise localization, to bands p11.2→pter of Y short arm.

Original languageEnglish (US)
Pages (from-to)271-276
Number of pages6
JournalHuman Genetics
Volume62
Issue number3
DOIs
StatePublished - Dec 1982
Externally publishedYes

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Phenotype
Prometaphase
Y Chromosome
X Chromosome
Karyotype
Fathers
Chromosomes
Staining and Labeling

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Magenis, R. E., Webb, M. J., McKean, R. S., Tomar, D., Allen, L. J., Kammer, H., ... Lovrien, E. (1982). Translocation(X;Y)(p22.33;p11.2) in XX males: Etiology of male phenotype. Human Genetics, 62(3), 271-276. https://doi.org/10.1007/BF00333535

Translocation(X;Y)(p22.33;p11.2) in XX males : Etiology of male phenotype. / Magenis, R. E.; Webb, M. J.; McKean, R. S.; Tomar, D.; Allen, L. J.; Kammer, H.; Van Dyke, D. L.; Lovrien, E.

In: Human Genetics, Vol. 62, No. 3, 12.1982, p. 271-276.

Research output: Contribution to journalArticle

Magenis, RE, Webb, MJ, McKean, RS, Tomar, D, Allen, LJ, Kammer, H, Van Dyke, DL & Lovrien, E 1982, 'Translocation(X;Y)(p22.33;p11.2) in XX males: Etiology of male phenotype', Human Genetics, vol. 62, no. 3, pp. 271-276. https://doi.org/10.1007/BF00333535
Magenis RE, Webb MJ, McKean RS, Tomar D, Allen LJ, Kammer H et al. Translocation(X;Y)(p22.33;p11.2) in XX males: Etiology of male phenotype. Human Genetics. 1982 Dec;62(3):271-276. https://doi.org/10.1007/BF00333535
Magenis, R. E. ; Webb, M. J. ; McKean, R. S. ; Tomar, D. ; Allen, L. J. ; Kammer, H. ; Van Dyke, D. L. ; Lovrien, E. / Translocation(X;Y)(p22.33;p11.2) in XX males : Etiology of male phenotype. In: Human Genetics. 1982 ; Vol. 62, No. 3. pp. 271-276.
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