Translocations involving the immunoglobulin heavy-chain locus are possible early genetic events in patients with primary systemic amyloidosis

Suzanne R. Hayman; Richard J. Bailey; Syed M. Jalal; Gregory J. Ahmann; Angela Dispenzieri; Morie A. Gertz; Philip R. Greipp; Robert A. Kyle; Martha Q. Lacy; S. Vincent Rajkumar; Thomas E. Witzig; John A. Lust; Rafael Fonseca

doi:10.1182/blood.V98.7.2266

Translocations involving the immunoglobulin heavy-chain locus are possible early genetic events in patients with primary systemic amyloidosis

Suzanne R. Hayman, Richard J. Bailey, Syed M. Jalal, Gregory J. Ahmann, Angela Dispenzieri, Morie A. Gertz, Philip R. Greipp, Robert A. Kyle, Martha Q. Lacy, S. Vincent Rajkumar, Thomas E. Witzig, John A. Lust, Rafael Fonseca

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Abstract

Primary systemic amyloidosis (AL) is a plasma cell (PC) dyscrasia with clinical similarities to multiple myeloma (MM) and monoclonal gammopathy of undetermined significance (MGUS), but its molecular basis is poorly understood. Translocations at the immunoglobulin heavy-chain (IgH) locus, 14q32, are likely early genetic events in both MM and MGUS and involve several nonrandom, recurrent, partner chromosomes such as 11q13, 16q23, and 4p16.3. Given the similarities between MM, MGUS, and AL, bone marrow clonal PCs were evaluated in 29 patients with AL using interphase fluorescence in situ hybridization (FISH) combined with immunofluorescence detection of the cytoplasmic light-chain (cig-FISH) for the presence of 14q32 translocations and the t(11;14)(q13;q32). Of 29 patients studied, 21 (72.4%) showed results compatible with the presence of a 14q32 translocation, and 16 (76.2%) of those had translocation (11;14)(q13;q32) for an overall prevalence of the abnormality of 55%. IgH translocations are common in AL, especially the t(11;14)(q13;q32).

Original language	English (US)
Pages (from-to)	2266-2268
Number of pages	3
Journal	Blood
Volume	98
Issue number	7
DOIs	https://doi.org/10.1182/blood.V98.7.2266
State	Published - Oct 1 2001

ASJC Scopus subject areas

Biochemistry
Immunology
Hematology
Cell Biology

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Hayman, S. R., Bailey, R. J., Jalal, S. M., Ahmann, G. J., Dispenzieri, A., Gertz, M. A., Greipp, P. R., Kyle, R. A., Lacy, M. Q., Vincent Rajkumar, S., Witzig, T. E., Lust, J. A., & Fonseca, R. (2001). Translocations involving the immunoglobulin heavy-chain locus are possible early genetic events in patients with primary systemic amyloidosis. Blood, 98(7), 2266-2268. https://doi.org/10.1182/blood.V98.7.2266

Hayman, SR, Bailey, RJ, Jalal, SM, Ahmann, GJ, Dispenzieri, A , Gertz, MA, Greipp, PR, Kyle, RA, Lacy, MQ , Vincent Rajkumar, S , Witzig, TE, Lust, JA & Fonseca, R 2001, 'Translocations involving the immunoglobulin heavy-chain locus are possible early genetic events in patients with primary systemic amyloidosis', Blood, vol. 98, no. 7, pp. 2266-2268. https://doi.org/10.1182/blood.V98.7.2266

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title = "Translocations involving the immunoglobulin heavy-chain locus are possible early genetic events in patients with primary systemic amyloidosis",

abstract = "Primary systemic amyloidosis (AL) is a plasma cell (PC) dyscrasia with clinical similarities to multiple myeloma (MM) and monoclonal gammopathy of undetermined significance (MGUS), but its molecular basis is poorly understood. Translocations at the immunoglobulin heavy-chain (IgH) locus, 14q32, are likely early genetic events in both MM and MGUS and involve several nonrandom, recurrent, partner chromosomes such as 11q13, 16q23, and 4p16.3. Given the similarities between MM, MGUS, and AL, bone marrow clonal PCs were evaluated in 29 patients with AL using interphase fluorescence in situ hybridization (FISH) combined with immunofluorescence detection of the cytoplasmic light-chain (cig-FISH) for the presence of 14q32 translocations and the t(11;14)(q13;q32). Of 29 patients studied, 21 (72.4%) showed results compatible with the presence of a 14q32 translocation, and 16 (76.2%) of those had translocation (11;14)(q13;q32) for an overall prevalence of the abnormality of 55%. IgH translocations are common in AL, especially the t(11;14)(q13;q32).",

author = "Hayman, {Suzanne R.} and Bailey, {Richard J.} and Jalal, {Syed M.} and Ahmann, {Gregory J.} and Angela Dispenzieri and Gertz, {Morie A.} and Greipp, {Philip R.} and Kyle, {Robert A.} and Lacy, {Martha Q.} and {Vincent Rajkumar}, S. and Witzig, {Thomas E.} and Lust, {John A.} and Rafael Fonseca",

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doi = "10.1182/blood.V98.7.2266",

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T1 - Translocations involving the immunoglobulin heavy-chain locus are possible early genetic events in patients with primary systemic amyloidosis

AU - Hayman, Suzanne R.

AU - Bailey, Richard J.

AU - Jalal, Syed M.

AU - Ahmann, Gregory J.

AU - Dispenzieri, Angela

AU - Gertz, Morie A.

AU - Greipp, Philip R.

AU - Kyle, Robert A.

AU - Lacy, Martha Q.

AU - Vincent Rajkumar, S.

AU - Witzig, Thomas E.

AU - Lust, John A.

AU - Fonseca, Rafael

PY - 2001/10/1

Y1 - 2001/10/1

N2 - Primary systemic amyloidosis (AL) is a plasma cell (PC) dyscrasia with clinical similarities to multiple myeloma (MM) and monoclonal gammopathy of undetermined significance (MGUS), but its molecular basis is poorly understood. Translocations at the immunoglobulin heavy-chain (IgH) locus, 14q32, are likely early genetic events in both MM and MGUS and involve several nonrandom, recurrent, partner chromosomes such as 11q13, 16q23, and 4p16.3. Given the similarities between MM, MGUS, and AL, bone marrow clonal PCs were evaluated in 29 patients with AL using interphase fluorescence in situ hybridization (FISH) combined with immunofluorescence detection of the cytoplasmic light-chain (cig-FISH) for the presence of 14q32 translocations and the t(11;14)(q13;q32). Of 29 patients studied, 21 (72.4%) showed results compatible with the presence of a 14q32 translocation, and 16 (76.2%) of those had translocation (11;14)(q13;q32) for an overall prevalence of the abnormality of 55%. IgH translocations are common in AL, especially the t(11;14)(q13;q32).

AB - Primary systemic amyloidosis (AL) is a plasma cell (PC) dyscrasia with clinical similarities to multiple myeloma (MM) and monoclonal gammopathy of undetermined significance (MGUS), but its molecular basis is poorly understood. Translocations at the immunoglobulin heavy-chain (IgH) locus, 14q32, are likely early genetic events in both MM and MGUS and involve several nonrandom, recurrent, partner chromosomes such as 11q13, 16q23, and 4p16.3. Given the similarities between MM, MGUS, and AL, bone marrow clonal PCs were evaluated in 29 patients with AL using interphase fluorescence in situ hybridization (FISH) combined with immunofluorescence detection of the cytoplasmic light-chain (cig-FISH) for the presence of 14q32 translocations and the t(11;14)(q13;q32). Of 29 patients studied, 21 (72.4%) showed results compatible with the presence of a 14q32 translocation, and 16 (76.2%) of those had translocation (11;14)(q13;q32) for an overall prevalence of the abnormality of 55%. IgH translocations are common in AL, especially the t(11;14)(q13;q32).

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Translocations involving the immunoglobulin heavy-chain locus are possible early genetic events in patients with primary systemic amyloidosis

Abstract

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