Abstract
B-cell prolymphocytic leukemia is a relatively rare lymphoproliferative disorder. No specific cytogenetic abnormality has yet been associated with it. The most common translocation reported in patients with this disease is t(11;14)(q13;q32). We describe the case of a patient with B-cell prolymphocytic leukemia and a hitherto unreported genetic translocation (8;14)(q24;q32) as the sole genetic abnormality, classically seen in patients with B-cell acute lymphoblastic leukemia/Burkitt lymphoma. This patient presented with an asymptomatic leukocytosis and splenomegaly. Her marrow showed lymphoid hyperplasia, with immunophenotyping consistent with prolymphocytic leukemia; however, t(8;14)(q24;q32) was the only cytogenetic aberration with both standard karyotyping and fluorescence in situ hybridization analysis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 156-158 |
| Number of pages | 3 |
| Journal | Cancer Genetics and Cytogenetics |
| Volume | 150 |
| Issue number | 2 |
| DOIs | |
| State | Published - Apr 15 2004 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cancer Research
- Genetics
- Molecular Biology
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Translocation (8;14)(q24;q32) as the sole cytogenetic abnormality in B-cell prolymphocytic leukemia. / Kuriakose, Philip; Perveen, Nusrat; Maeda, Koichi; Wiktor, Anne; Van Dyke, Daniel L.
In: Cancer Genetics and Cytogenetics, Vol. 150, No. 2, 15.04.2004, p. 156-158.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Translocation (8;14)(q24;q32) as the sole cytogenetic abnormality in B-cell prolymphocytic leukemia
AU - Kuriakose, Philip
AU - Perveen, Nusrat
AU - Maeda, Koichi
AU - Wiktor, Anne
AU - Van Dyke, Daniel L.
PY - 2004/4/15
Y1 - 2004/4/15
N2 - B-cell prolymphocytic leukemia is a relatively rare lymphoproliferative disorder. No specific cytogenetic abnormality has yet been associated with it. The most common translocation reported in patients with this disease is t(11;14)(q13;q32). We describe the case of a patient with B-cell prolymphocytic leukemia and a hitherto unreported genetic translocation (8;14)(q24;q32) as the sole genetic abnormality, classically seen in patients with B-cell acute lymphoblastic leukemia/Burkitt lymphoma. This patient presented with an asymptomatic leukocytosis and splenomegaly. Her marrow showed lymphoid hyperplasia, with immunophenotyping consistent with prolymphocytic leukemia; however, t(8;14)(q24;q32) was the only cytogenetic aberration with both standard karyotyping and fluorescence in situ hybridization analysis.
AB - B-cell prolymphocytic leukemia is a relatively rare lymphoproliferative disorder. No specific cytogenetic abnormality has yet been associated with it. The most common translocation reported in patients with this disease is t(11;14)(q13;q32). We describe the case of a patient with B-cell prolymphocytic leukemia and a hitherto unreported genetic translocation (8;14)(q24;q32) as the sole genetic abnormality, classically seen in patients with B-cell acute lymphoblastic leukemia/Burkitt lymphoma. This patient presented with an asymptomatic leukocytosis and splenomegaly. Her marrow showed lymphoid hyperplasia, with immunophenotyping consistent with prolymphocytic leukemia; however, t(8;14)(q24;q32) was the only cytogenetic aberration with both standard karyotyping and fluorescence in situ hybridization analysis.
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UR - http://www.scopus.com/inward/citedby.url?scp=1842506365&partnerID=8YFLogxK
U2 - 10.1016/j.cancergencyto.2003.09.009
DO - 10.1016/j.cancergencyto.2003.09.009
M3 - Article
C2 - 15066324
AN - SCOPUS:1842506365
VL - 150
SP - 156
EP - 158
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
SN - 0165-4608
IS - 2
ER -