Abstract
B-cell prolymphocytic leukemia is a relatively rare lymphoproliferative disorder. No specific cytogenetic abnormality has yet been associated with it. The most common translocation reported in patients with this disease is t(11;14)(q13;q32). We describe the case of a patient with B-cell prolymphocytic leukemia and a hitherto unreported genetic translocation (8;14)(q24;q32) as the sole genetic abnormality, classically seen in patients with B-cell acute lymphoblastic leukemia/Burkitt lymphoma. This patient presented with an asymptomatic leukocytosis and splenomegaly. Her marrow showed lymphoid hyperplasia, with immunophenotyping consistent with prolymphocytic leukemia; however, t(8;14)(q24;q32) was the only cytogenetic aberration with both standard karyotyping and fluorescence in situ hybridization analysis.
Original language | English (US) |
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Pages (from-to) | 156-158 |
Number of pages | 3 |
Journal | Cancer Genetics and Cytogenetics |
Volume | 150 |
Issue number | 2 |
DOIs | |
State | Published - Apr 15 2004 |
ASJC Scopus subject areas
- Molecular Biology
- Genetics
- Cancer Research