Translational potential of tumor exosomes in diagnosis and therapy

Naureen Javeed, Debabrata Mukhopadhyay

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Exosomes are endocytic-derived nanovesicles that are secreted by nearly all cell types in the body. Not only do exosomes contain important bioactive cargoes, but they also serve as direct cellular conduits by transporting these cargoes both proximally and distally to target cells. The horizontal exchange of cellular material mediated by exosomes has been shown to influence both normal physiology and disease states, such as cancer. Compelling evidence supports the role of exosomes in altering the tumor microenvironment, in promoting angiogenesis and immune modulation, and in establishing the premetastatic niche. Therefore, exosomes may not only provide a potential mechanistic link to tumor metastasis but could also be used as cancer biomarkers for diagnostic and therapeutic regimes.

Original languageEnglish (US)
Title of host publicationDiagnostic and Therapeutic Applications of Exosomes in Cancer
PublisherElsevier
Pages343-353
Number of pages11
ISBN (Electronic)9780128127742
ISBN (Print)9780128128046
DOIs
StatePublished - Jan 1 2018

Keywords

  • Biomarker
  • Cancer
  • Exosomes
  • Metastasis
  • Therapeutics
  • Tumor microenvironment

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Fingerprint Dive into the research topics of 'Translational potential of tumor exosomes in diagnosis and therapy'. Together they form a unique fingerprint.

  • Cite this

    Javeed, N., & Mukhopadhyay, D. (2018). Translational potential of tumor exosomes in diagnosis and therapy. In Diagnostic and Therapeutic Applications of Exosomes in Cancer (pp. 343-353). Elsevier. https://doi.org/10.1016/B978-0-12-812774-2.00019-5