Translational opportunities for microfluidic technologies to enable precision epigenomics

Yi Xu, Steven R. Doonan, Tamas Ordog, Ryan C. Bailey

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Personalizing health care by taking genetic, environmental, and lifestyle factors into account is central to modern medicine. The crucial and pervasive roles epigenetic factors play in shaping gene−environment interactions are now well recognized. However, identifying robust epigenetic biomarkers and translating them to clinical tests has been difficult due in part to limitations of available platforms to detect epigenetic features genome-wide (epigenomic assays). This Feature introduces several important prospects for precision epigenomics, highlights capabilities and limitations of current laboratory technologies, and emphasizes opportunities for microfluidic tools to facilitate translation of epigenetic analyses to the clinic, with a particular focus on methods to profile gene-associated histone modifications and their impacts on chromatin structure and gene expression.

Original languageEnglish (US)
Pages (from-to)7989-7997
Number of pages9
JournalAnalytical Chemistry
Volume92
Issue number12
DOIs
StatePublished - Jun 16 2020

ASJC Scopus subject areas

  • Analytical Chemistry

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