TY - JOUR
T1 - Translational opportunities for microfluidic technologies to enable precision epigenomics
AU - Xu, Yi
AU - Doonan, Steven R.
AU - Ordog, Tamas
AU - Bailey, Ryan C.
N1 - Funding Information:
This work was supported by NIH Grant R21 CA191186 to R.C.B. and T.O. T.O. was also supported by NIH Grants R01 DK58185 and P01 DK68055 and by the Mayo Clinic Center for Individualized Medicine.
Publisher Copyright:
© 2020 American Chemical Society
PY - 2020/6/16
Y1 - 2020/6/16
N2 - Personalizing health care by taking genetic, environmental, and lifestyle factors into account is central to modern medicine. The crucial and pervasive roles epigenetic factors play in shaping gene−environment interactions are now well recognized. However, identifying robust epigenetic biomarkers and translating them to clinical tests has been difficult due in part to limitations of available platforms to detect epigenetic features genome-wide (epigenomic assays). This Feature introduces several important prospects for precision epigenomics, highlights capabilities and limitations of current laboratory technologies, and emphasizes opportunities for microfluidic tools to facilitate translation of epigenetic analyses to the clinic, with a particular focus on methods to profile gene-associated histone modifications and their impacts on chromatin structure and gene expression.
AB - Personalizing health care by taking genetic, environmental, and lifestyle factors into account is central to modern medicine. The crucial and pervasive roles epigenetic factors play in shaping gene−environment interactions are now well recognized. However, identifying robust epigenetic biomarkers and translating them to clinical tests has been difficult due in part to limitations of available platforms to detect epigenetic features genome-wide (epigenomic assays). This Feature introduces several important prospects for precision epigenomics, highlights capabilities and limitations of current laboratory technologies, and emphasizes opportunities for microfluidic tools to facilitate translation of epigenetic analyses to the clinic, with a particular focus on methods to profile gene-associated histone modifications and their impacts on chromatin structure and gene expression.
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U2 - 10.1021/acs.analchem.0c01288
DO - 10.1021/acs.analchem.0c01288
M3 - Article
AN - SCOPUS:85087734737
SN - 0003-2700
VL - 92
SP - 7989
EP - 7997
JO - Analytical Chemistry
JF - Analytical Chemistry
IS - 12
ER -