Translational opportunities for microfluidic technologies to enable precision epigenomics

Yi Xu; Steven R. Doonan; Tamas Ordog; Ryan C. Bailey

doi:10.1021/acs.analchem.0c01288

Translational opportunities for microfluidic technologies to enable precision epigenomics

Yi Xu, Steven R. Doonan, Tamas Ordog, Ryan C. Bailey

Physiology & Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Personalizing health care by taking genetic, environmental, and lifestyle factors into account is central to modern medicine. The crucial and pervasive roles epigenetic factors play in shaping gene−environment interactions are now well recognized. However, identifying robust epigenetic biomarkers and translating them to clinical tests has been difficult due in part to limitations of available platforms to detect epigenetic features genome-wide (epigenomic assays). This Feature introduces several important prospects for precision epigenomics, highlights capabilities and limitations of current laboratory technologies, and emphasizes opportunities for microfluidic tools to facilitate translation of epigenetic analyses to the clinic, with a particular focus on methods to profile gene-associated histone modifications and their impacts on chromatin structure and gene expression.

Original language	English (US)
Pages (from-to)	7989-7997
Number of pages	9
Journal	Analytical Chemistry
Volume	92
Issue number	12
DOIs	https://doi.org/10.1021/acs.analchem.0c01288
State	Published - Jun 16 2020

ASJC Scopus subject areas

Analytical Chemistry

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abstract = "Personalizing health care by taking genetic, environmental, and lifestyle factors into account is central to modern medicine. The crucial and pervasive roles epigenetic factors play in shaping gene−environment interactions are now well recognized. However, identifying robust epigenetic biomarkers and translating them to clinical tests has been difficult due in part to limitations of available platforms to detect epigenetic features genome-wide (epigenomic assays). This Feature introduces several important prospects for precision epigenomics, highlights capabilities and limitations of current laboratory technologies, and emphasizes opportunities for microfluidic tools to facilitate translation of epigenetic analyses to the clinic, with a particular focus on methods to profile gene-associated histone modifications and their impacts on chromatin structure and gene expression.",

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AB - Personalizing health care by taking genetic, environmental, and lifestyle factors into account is central to modern medicine. The crucial and pervasive roles epigenetic factors play in shaping gene−environment interactions are now well recognized. However, identifying robust epigenetic biomarkers and translating them to clinical tests has been difficult due in part to limitations of available platforms to detect epigenetic features genome-wide (epigenomic assays). This Feature introduces several important prospects for precision epigenomics, highlights capabilities and limitations of current laboratory technologies, and emphasizes opportunities for microfluidic tools to facilitate translation of epigenetic analyses to the clinic, with a particular focus on methods to profile gene-associated histone modifications and their impacts on chromatin structure and gene expression.

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Translational opportunities for microfluidic technologies to enable precision epigenomics

Abstract

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