Transient activation of C-MYC protooncogene expression in leydig cells by human chorionic gonadotropin

T. Lin, J. Blaisdell, K. W. Barbour, E. A. Thompson

Research output: Contribution to journalArticle

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Abstract

This study evaluated the effects of in vivo administration of human chorionic gonadotropin (hCG) on c-myc oncogene expression in Leydig cells. Sprague-Dawley rats (46-50 days old) were treated with hCG (10 units, i.p.), and purified Leydig cells were isolated 1-24 h later. HCG caused a transient elevation of c-myc mRNA in 4 h and returned to normal or lower than normal levels at 24 h. There was no change in c-fos or β-actin mRNA levels. Our results suggest that the growth promoting effects of hCG on Leydig cells may be mediated by the transient expression of c-myc protooncogene.

Original languageEnglish (US)
Pages (from-to)121-126
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume157
Issue number1
DOIs
StatePublished - Nov 30 1988

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ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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