Transglutaminase autoantibodies in dermatitis herpetiformis and celiac sprue

Eric V. Marietta, Michael J. Camilleri, Luis A. Castro, Patricia K. Krause, Mark R. Pittelkow, Joseph A. Murray

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Dermatitis herpetiformis (DH) is an autoimmune blistering skin disorder that is associated with intestinal gluten sensitivity. Epidermal transglutaminase (TGe) and closely related tissue transglutaminase (tTG) are considered to be autoantigens in DH, because a majority of DH patients have IgA specific for TGe and for tTG. It is unknown where and how these autoantigen-specific IgAs are generated in DH. Results reported in this paper on nine DH patients on a gluten containing diet demonstrate that the levels of circulating anti-tTG IgA and anti-TGe IgA in DH are correlated with each other and that both appear to be correlated with the degree (extent) of enteropathy. An analysis of 15 untreated celiac sprue (CS) patients demonstrated that approximately 33% of CS patients had elevated levels of anti-TGe IgA. These results would indicate that intestinal damage is associated with the production of anti-tTG IgA and anti-TGe IgA in DH patients.

Original languageEnglish (US)
Pages (from-to)332-335
Number of pages4
JournalJournal of Investigative Dermatology
Volume128
Issue number2
DOIs
StatePublished - Feb 2008

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

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