Transgenic Animal Models of Proteinopathies

Naruhiko Sahara, Heather Melrose, Simon D'alton, Jada Lewis

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Proteinopathies are a family of neurodegenerative disorders that are neuropathologically characterized by the abnormal intracellular and/or extracellular aggregation of one or more proteins. These diseases can be further subdivided based on the specific protein aggregates formed. In this chapter, we focus on the mouse lines that have been generated to model four major families of proteinopathies termed the tauopathies, amyloidosis, synucleinopathies, and TDP-43 proteinopathies.

Original languageEnglish (US)
Title of host publicationNeurodegeneration
Subtitle of host publicationThe Molecular Pathology of Dementia and Movement Disorders: Second Edition
PublisherWiley-Blackwell
Pages26-36
Number of pages11
ISBN (Print)9781405196932
DOIs
StatePublished - Sep 21 2011

Keywords

  • Alzheimer's disease
  • Amyloidosis
  • Amyotrophic lateral sclerosis
  • Frontotemporal dementia
  • Neurodegenerative disorders
  • Parkinson's disease
  • Protein aggregates
  • Synucleinopathies
  • TDP-43 proteinopathies
  • Tauopathies

ASJC Scopus subject areas

  • Medicine(all)

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    Sahara, N., Melrose, H., D'alton, S., & Lewis, J. (2011). Transgenic Animal Models of Proteinopathies. In Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders: Second Edition (pp. 26-36). Wiley-Blackwell. https://doi.org/10.1002/9781444341256.ch7