Abstract
Proteinopathies are a family of neurodegenerative disorders that are neuropathologically characterized by the abnormal intracellular and/or extracellular aggregation of one or more proteins. These diseases can be further subdivided based on the specific protein aggregates formed. In this chapter, we focus on the mouse lines that have been generated to model four major families of proteinopathies termed the tauopathies, amyloidosis, synucleinopathies, and TDP-43 proteinopathies.
| Original language | English (US) |
|---|---|
| Title of host publication | Neurodegeneration |
| Subtitle of host publication | The Molecular Pathology of Dementia and Movement Disorders: Second Edition |
| Publisher | Wiley-Blackwell |
| Pages | 26-36 |
| Number of pages | 11 |
| ISBN (Print) | 9781405196932 |
| DOIs | |
| State | Published - Sep 21 2011 |
Keywords
- Alzheimer's disease
- Amyloidosis
- Amyotrophic lateral sclerosis
- Frontotemporal dementia
- Neurodegenerative disorders
- Parkinson's disease
- Protein aggregates
- Synucleinopathies
- TDP-43 proteinopathies
- Tauopathies
ASJC Scopus subject areas
- Medicine(all)