Transforming growth factor type β regulation of actin mRNA

Edward B. Leof, Jacqueline A. Proper, Michael J. Getz, Harold L. Moses

Research output: Contribution to journalArticlepeer-review

66 Scopus citations

Abstract

Stimulation of quiescent cultures of AKR‐2B cells with transforming growth factor type β (TGFβ) resulted in a transitory increase in actin cytoplasmic poly(A) + RNA. Levels of actin mRNA peaked approximately 4–8 hours subsequent to TGFβ addition and approached basal levels by 24 hours. The accumulation of actin transcripts was dose dependent and insensitive to inhibitors of protein synthesis; 1–3 ng/ml TGFβ induced maximal actin gene expression. Actin isotype‐specific probes demonstrated that both β‐ and γ‐cytoplasmic actins are induced by TGFβ.

Original languageEnglish (US)
Pages (from-to)83-88
Number of pages6
JournalJournal of Cellular Physiology
Volume127
Issue number1
DOIs
StatePublished - Apr 1986

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Cell Biology

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