Abstract
Stimulation of quiescent cultures of AKR‐2B cells with transforming growth factor type β (TGFβ) resulted in a transitory increase in actin cytoplasmic poly(A) + RNA. Levels of actin mRNA peaked approximately 4–8 hours subsequent to TGFβ addition and approached basal levels by 24 hours. The accumulation of actin transcripts was dose dependent and insensitive to inhibitors of protein synthesis; 1–3 ng/ml TGFβ induced maximal actin gene expression. Actin isotype‐specific probes demonstrated that both β‐ and γ‐cytoplasmic actins are induced by TGFβ.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 83-88 |
| Number of pages | 6 |
| Journal | Journal of Cellular Physiology |
| Volume | 127 |
| Issue number | 1 |
| DOIs | |
| State | Published - Apr 1986 |
ASJC Scopus subject areas
- Physiology
- Clinical Biochemistry
- Cell Biology