Primary sclerosing cholangitis (PSC) is a chronic cholestatic disorder of unknown etiology characterized by progressive fibrosis and stricturing of the biliary tract. Transforming growth factor-β (TGF-β) is a family of cytokines produced by biliary tract epithelial cells that promote fibrinogenesis. Our objective was to determine whether TGF-β levels are increased in the blood and/or bile of PSC patients compared to patients with other causes of obstructed biliary tracts (controls). Serum and bile TGF-β levels were documented by enzyme-linked immunoassay in 10 adult PSC and 10 control patients obtained at the time of endoscopic retrograde cholangiography. Serum and bile TGF-β levels were similar in the two groups (PSC versus control sera, 33.4 ± 4.3 versus 27.5 ± 7.7 ng/ml, and bile, 367 ± 275 versus 457 ± 247 ng/mg, respectively). Serum and bile TGF-β levels are not increased in patients with PSC. Hence, the results of this pilot study do not support the hypotheses that PSC is caused by dysregulated TGF-β expression.
|Original language||English (US)|
|Number of pages||4|
|Journal||Digestive diseases and sciences|
|State||Published - Jan 2004|
- Liver disease
- Primary sclerosing cholangitis
ASJC Scopus subject areas