Transforming Growth Factor-β (TGF-β) Protein Levels Are Not Elevated in the Blood or Bile of Patients with Primary Sclerosing Cholangitis: A Pilot Study

J. K. Watt, K. Hawkins, M. Zhang, J. Lipschitz, G. Sandha, Y. Gong, J. Uhanova, G. Y. Minuk

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Primary sclerosing cholangitis (PSC) is a chronic cholestatic disorder of unknown etiology characterized by progressive fibrosis and stricturing of the biliary tract. Transforming growth factor-β (TGF-β) is a family of cytokines produced by biliary tract epithelial cells that promote fibrinogenesis. Our objective was to determine whether TGF-β levels are increased in the blood and/or bile of PSC patients compared to patients with other causes of obstructed biliary tracts (controls). Serum and bile TGF-β levels were documented by enzyme-linked immunoassay in 10 adult PSC and 10 control patients obtained at the time of endoscopic retrograde cholangiography. Serum and bile TGF-β levels were similar in the two groups (PSC versus control sera, 33.4 ± 4.3 versus 27.5 ± 7.7 ng/ml, and bile, 367 ± 275 versus 457 ± 247 ng/mg, respectively). Serum and bile TGF-β levels are not increased in patients with PSC. Hence, the results of this pilot study do not support the hypotheses that PSC is caused by dysregulated TGF-β expression.

Original languageEnglish (US)
Pages (from-to)5-8
Number of pages4
JournalDigestive diseases and sciences
Volume49
Issue number1
DOIs
StatePublished - Jan 2004

Keywords

  • Bile
  • Cholestasis
  • Collagen
  • Cytokines
  • Fibrosis
  • Liver disease
  • Primary sclerosing cholangitis
  • TGF-β

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

Fingerprint Dive into the research topics of 'Transforming Growth Factor-β (TGF-β) Protein Levels Are Not Elevated in the Blood or Bile of Patients with Primary Sclerosing Cholangitis: A Pilot Study'. Together they form a unique fingerprint.

Cite this