Transformation of the proteasome with age-related macular degeneration

Cheryl M. Ethen, Stacy A. Hussong, Cavan Reilly, Xiao Feng, Timothy W. Olsen, Deborah A. Ferrington

Research output: Contribution to journalArticle

64 Scopus citations

Abstract

The proteasome mediates pathways associated with oxidative stress and inflammation, two pathogenic events correlated with age-related macular degeneration (AMD). In human donor eyes corresponding to four stages of AMD, we found the proteasomal chymotrypsin-like activity increased in neurosensory retina with disease progression. Increased activity correlated with a dramatic increase in the inducible subunits of the immunoproteasome, which was not due to an increase in CD45 positive immune cells in the retina. The novel observation of proteasome transformation may reflect retinal response to local inflammation or oxidative stress with AMD.

Original languageEnglish (US)
Pages (from-to)885-890
Number of pages6
JournalFEBS Letters
Volume581
Issue number5
DOIs
StatePublished - Mar 6 2007

Keywords

  • 20S Proteasome
  • Age-related macular degeneration
  • Chymotrypsin-like activity
  • Immunoproteasome

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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  • Cite this

    Ethen, C. M., Hussong, S. A., Reilly, C., Feng, X., Olsen, T. W., & Ferrington, D. A. (2007). Transformation of the proteasome with age-related macular degeneration. FEBS Letters, 581(5), 885-890. https://doi.org/10.1016/j.febslet.2007.01.061