Transdermal fentanyl in the management of cancer pain in ambulatory patients: An open-label pilot study

Julie E. Hammack, James A. Mailliard, Charles L. Loprinzi, Raylene M. Respond, Judith R. O'Fallon, Mary B. Wilwerding, Nicholas F. Reuter, John C. Michalak, Pat Fidler, Angela W. Miser

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

We performed an open label pilot study to define analgesic efficacy, acceptability, and toxicity of transdermal fentanyl in an ambulatory population of patients with cancer pain. Our 7-day study included 35 patients all of whom had failed a trial of an opioid analgesic conventionally used for moderate pain. Patients received either a 25 μg/hr or 50 μg/hr fentanyl transdermal patch depending on prior opioid dose. Pain was measured daily utilizing visual analogue (VAS) and categorical (CAT) scales. Hours of nighttime sleep, quality of life, toxicities, and use of rescue medication were also assessed. There was a 24%-29% reduction in mean VAS and CAT pain scores as compared with the baseline and a 25% increase in mean hours of nighttime sleep. Fifty-nine percent of those patients responding (46% of all study patients) were satisfied to very satisfied with the analgesia provided by transdermal fentanyl. Six percent of all study patients were not at all satisfied with the pain relief obtained. Toxicities were similar to those seen with other opioids. No patient developed severe sedation or respiratory depression. The 25-50 μg/hr patch appears to be a safe starting dosage in ambulatory patients previously receiving opioids conventionally used for moderate pain.

Original languageEnglish (US)
Pages (from-to)234-240
Number of pages7
JournalJournal of Pain and Symptom Management
Volume12
Issue number4
DOIs
StatePublished - Oct 1996

Keywords

  • Transdermal fentanyl
  • cancer pain
  • opioids

ASJC Scopus subject areas

  • Nursing(all)
  • Clinical Neurology
  • Anesthesiology and Pain Medicine

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    Hammack, J. E., Mailliard, J. A., Loprinzi, C. L., Respond, R. M., O'Fallon, J. R., Wilwerding, M. B., Reuter, N. F., Michalak, J. C., Fidler, P., & Miser, A. W. (1996). Transdermal fentanyl in the management of cancer pain in ambulatory patients: An open-label pilot study. Journal of Pain and Symptom Management, 12(4), 234-240. https://doi.org/10.1016/0885-3924(96)00191-1