Transdermal clonidine for ameliorating post-orchiectomy hot flashes

C. L. Loprinzi; R. M. Goldberg; J. R. O'Fallon; S. K. Quella; A. W. Miser; L. A. Mynderse; L. D. Brown; L. K. Tschetter; M. B. Wilwerding; A. M. Dose; J. E. Oesterling

doi:10.1016/S0022-5347(17)35034-6

Transdermal clonidine for ameliorating post-orchiectomy hot flashes

C. L. Loprinzi, R. M. Goldberg, J. R. O'Fallon, S. K. Quella, A. W. Miser, L. A. Mynderse, L. D. Brown, L. K. Tschetter, M. B. Wilwerding, A. M. Dose, J. E. Oesterling

Medical Oncology

Research output: Contribution to journal › Article › peer-review

82 Scopus citations

Abstract

To determine the efficacy of transdermal clonidine for alleviating post- orchiectomy hot flashes, a randomized, double-blind, crossover clinical trial was designed including 70 men with a history of prostate cancer who had undergone a medical or surgical orchiectomy and were suffering from hot flashes. The results of this study demonstrated that clonidine did not significantly decrease hot flash frequency or severity. Future research is necessary to find effective means of alleviating hot flashes in post- orchiectomy patients.

Original language	English (US)
Pages (from-to)	634-636
Number of pages	3
Journal	Journal of Urology
Volume	151
Issue number	3
DOIs	https://doi.org/10.1016/S0022-5347(17)35034-6
State	Published - 1994

Keywords

clonidine
flushing
orchiectomy
prostatic neoplasms

ASJC Scopus subject areas

Urology

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10.1016/S0022-5347(17)35034-6

Cite this

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title = "Transdermal clonidine for ameliorating post-orchiectomy hot flashes",

abstract = "To determine the efficacy of transdermal clonidine for alleviating post- orchiectomy hot flashes, a randomized, double-blind, crossover clinical trial was designed including 70 men with a history of prostate cancer who had undergone a medical or surgical orchiectomy and were suffering from hot flashes. The results of this study demonstrated that clonidine did not significantly decrease hot flash frequency or severity. Future research is necessary to find effective means of alleviating hot flashes in post- orchiectomy patients.",

keywords = "clonidine, flushing, orchiectomy, prostatic neoplasms",

author = "Loprinzi, {C. L.} and Goldberg, {R. M.} and O'Fallon, {J. R.} and Quella, {S. K.} and Miser, {A. W.} and Mynderse, {L. A.} and Brown, {L. D.} and Tschetter, {L. K.} and Wilwerding, {M. B.} and Dose, {A. M.} and Oesterling, {J. E.}",

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T1 - Transdermal clonidine for ameliorating post-orchiectomy hot flashes

AU - Loprinzi, C. L.

AU - Goldberg, R. M.

AU - O'Fallon, J. R.

AU - Quella, S. K.

AU - Miser, A. W.

AU - Mynderse, L. A.

AU - Brown, L. D.

AU - Tschetter, L. K.

AU - Wilwerding, M. B.

AU - Dose, A. M.

AU - Oesterling, J. E.

PY - 1994

Y1 - 1994

N2 - To determine the efficacy of transdermal clonidine for alleviating post- orchiectomy hot flashes, a randomized, double-blind, crossover clinical trial was designed including 70 men with a history of prostate cancer who had undergone a medical or surgical orchiectomy and were suffering from hot flashes. The results of this study demonstrated that clonidine did not significantly decrease hot flash frequency or severity. Future research is necessary to find effective means of alleviating hot flashes in post- orchiectomy patients.

AB - To determine the efficacy of transdermal clonidine for alleviating post- orchiectomy hot flashes, a randomized, double-blind, crossover clinical trial was designed including 70 men with a history of prostate cancer who had undergone a medical or surgical orchiectomy and were suffering from hot flashes. The results of this study demonstrated that clonidine did not significantly decrease hot flash frequency or severity. Future research is necessary to find effective means of alleviating hot flashes in post- orchiectomy patients.

KW - clonidine

KW - flushing

KW - orchiectomy

KW - prostatic neoplasms

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Transdermal clonidine for ameliorating post-orchiectomy hot flashes

Abstract

Keywords

ASJC Scopus subject areas

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