Transcriptional repressors, corepressors and chromatin modifying enzymes in T cell development

Michael J. Shapiro, Virginia Smith Shapiro

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

Gene expression is regulated by the combined action of transcriptional activators and transcriptional repressors. Transcriptional repressors function by recruiting corepressor complexes containing histone-modifying enzymes to specific sites within DNA. Chromatin modifying complexes are subsequently recruited, either directly by transcriptional repressors, or indirectly via corepressor complexes and/or histone modifications, to remodel chromatin into either a transcription-friendly 'open' form or an inhibitory 'closed' form. Transcriptional repressors, corepressors and chromatin modifying complexes play critical roles throughout T cell development. Here, we highlight those genes that function to repress transcription and that have been shown to be required for T cell development.

Original languageEnglish (US)
Pages (from-to)271-281
Number of pages11
JournalCytokine
Volume53
Issue number3
DOIs
StatePublished - Mar 1 2011

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Keywords

  • Chromatin
  • Corepressors
  • Repressors
  • T cell development
  • Transcription

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Hematology
  • Molecular Biology

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