Transcriptional repressors, corepressors and chromatin modifying enzymes in T cell development

Michael J. Shapiro, Virginia M Shapiro

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Gene expression is regulated by the combined action of transcriptional activators and transcriptional repressors. Transcriptional repressors function by recruiting corepressor complexes containing histone-modifying enzymes to specific sites within DNA. Chromatin modifying complexes are subsequently recruited, either directly by transcriptional repressors, or indirectly via corepressor complexes and/or histone modifications, to remodel chromatin into either a transcription-friendly 'open' form or an inhibitory 'closed' form. Transcriptional repressors, corepressors and chromatin modifying complexes play critical roles throughout T cell development. Here, we highlight those genes that function to repress transcription and that have been shown to be required for T cell development.

Original languageEnglish (US)
Pages (from-to)271-281
Number of pages11
JournalCytokine
Volume53
Issue number3
DOIs
StatePublished - Mar 2011

Fingerprint

Co-Repressor Proteins
T-cells
Chromatin
Transcription
T-Lymphocytes
Histones
Enzymes
Histone Code
Gene expression
Genes
Gene Expression
DNA

Keywords

  • Chromatin
  • Corepressors
  • Repressors
  • T cell development
  • Transcription

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Hematology
  • Biochemistry
  • Molecular Biology

Cite this

Transcriptional repressors, corepressors and chromatin modifying enzymes in T cell development. / Shapiro, Michael J.; Shapiro, Virginia M.

In: Cytokine, Vol. 53, No. 3, 03.2011, p. 271-281.

Research output: Contribution to journalArticle

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