TY - JOUR
T1 - Transcriptional regulation during myelopoiesis
AU - Lenny, Noel
AU - Westendorf, Jennifer J.
AU - Hiebert, Scott W.
N1 - Funding Information:
We thank Drs Paul Lui, Nancy Speck, and Dong-Er Zhang for sharing their data with us prior to publication. We also thank Drs. Bart Lutterbach, John Nip, Linda Shapiro, David Strom, and Sue Vallance for critical reading of the manuscript and skillful artwork (JN). SWH is supported by NIH RO1-CA64140, NIH RO1-AG13726, and ACS JFRA-591.
PY - 1997/8
Y1 - 1997/8
N2 - The coordinated production of all blood cells from a common stem cell is a highly regulated process involving successive stages of commitment and differentiation. From analyses of mice deficient in transcription factor genes and from the characterizations of chromosome breakpoints in human leukemias, it has become evident that transcription factors are important regulators of hematopoiesis. During myelopoiesis, which includes the development of granulocytic and monocytic lineages, transcription factors from several families are active, including AML1/CBFβ, C/EBP, Ets, c-Myb, HOX, and MZF-1. Few of these factors are expressed exclusively in myeloid cells; instead it appears that they cooperatively regulate transcription of myeloid-specific genes. Here we discuss recent advances in transcriptional regulation during myelopoiesis.
AB - The coordinated production of all blood cells from a common stem cell is a highly regulated process involving successive stages of commitment and differentiation. From analyses of mice deficient in transcription factor genes and from the characterizations of chromosome breakpoints in human leukemias, it has become evident that transcription factors are important regulators of hematopoiesis. During myelopoiesis, which includes the development of granulocytic and monocytic lineages, transcription factors from several families are active, including AML1/CBFβ, C/EBP, Ets, c-Myb, HOX, and MZF-1. Few of these factors are expressed exclusively in myeloid cells; instead it appears that they cooperatively regulate transcription of myeloid-specific genes. Here we discuss recent advances in transcriptional regulation during myelopoiesis.
KW - AML
KW - Hematopoiesis
KW - Myeloid leukemias
KW - Myelopoiesis
KW - Transcription factors
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U2 - 10.1023/A:1006859700409
DO - 10.1023/A:1006859700409
M3 - Review article
C2 - 9291089
AN - SCOPUS:0031214702
SN - 0301-4851
VL - 24
SP - 157
EP - 168
JO - Molecular Biology Reports
JF - Molecular Biology Reports
IS - 3
ER -