Transcriptional regulation and its misregulation in Alzheimer's disease

Xiao Fen Chen, Yun Wu Zhang, Huaxi Xu, Guojun D Bu

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by loss of memory and cognitive function. A key neuropathological event in AD is the accumulation of amyloid-β (Aβ) peptide. The production and clearance of Aβ in the brain are regulated by a large group of genes. The expression levels of these genes must be fine-tuned in the brain to keep Aβ at a balanced amount under physiological condition. Misregulation of AD genes has been found to either increase AD risk or accelerate the disease progression. In recent years, important progress has been made in uncovering the regulatory elements and transcriptional factors that guide the expression of these genes. In this review, we describe the mechanisms of transcriptional regulation for the known AD genes and the misregualtion that leads to AD susceptibility.

Original languageEnglish (US)
Article number44
JournalMolecular Brain
Volume6
Issue number1
DOIs
StatePublished - 2013
Externally publishedYes

Fingerprint

Alzheimer Disease
Transcriptional Regulatory Elements
Genes
Gene Expression
Disease Susceptibility
Memory Disorders
Brain
Amyloid
Neurodegenerative Diseases
Cognition
Disease Progression
Peptides

Keywords

  • Alzheimer's disease
  • Amyloid-β
  • Polymorphism
  • Transcription factors
  • Transcriptional regulatory element

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Molecular Biology

Cite this

Transcriptional regulation and its misregulation in Alzheimer's disease. / Chen, Xiao Fen; Zhang, Yun Wu; Xu, Huaxi; Bu, Guojun D.

In: Molecular Brain, Vol. 6, No. 1, 44, 2013.

Research output: Contribution to journalArticle

Chen, Xiao Fen ; Zhang, Yun Wu ; Xu, Huaxi ; Bu, Guojun D. / Transcriptional regulation and its misregulation in Alzheimer's disease. In: Molecular Brain. 2013 ; Vol. 6, No. 1.
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