Transcriptional regulation and its misregulation in Alzheimer's disease

Xiao Fen Chen; Yun Wu Zhang; Huaxi Xu; Guojun Bu

doi:10.1186/1756-6606-6-44

Transcriptional regulation and its misregulation in Alzheimer's disease

Xiao Fen Chen, Yun Wu Zhang, Huaxi Xu, Guojun Bu

Neuroscience

Research output: Contribution to journal › Review article › peer-review

27 Scopus citations

Abstract

Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by loss of memory and cognitive function. A key neuropathological event in AD is the accumulation of amyloid-β (Aβ) peptide. The production and clearance of Aβ in the brain are regulated by a large group of genes. The expression levels of these genes must be fine-tuned in the brain to keep Aβ at a balanced amount under physiological condition. Misregulation of AD genes has been found to either increase AD risk or accelerate the disease progression. In recent years, important progress has been made in uncovering the regulatory elements and transcriptional factors that guide the expression of these genes. In this review, we describe the mechanisms of transcriptional regulation for the known AD genes and the misregualtion that leads to AD susceptibility.

Original language	English (US)
Article number	44
Journal	Molecular brain
Volume	6
Issue number	1
DOIs	https://doi.org/10.1186/1756-6606-6-44
State	Published - 2013

Keywords

Alzheimer's disease
Amyloid-β
Polymorphism
Transcription factors
Transcriptional regulatory element

ASJC Scopus subject areas

Molecular Biology
Cellular and Molecular Neuroscience

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10.1186/1756-6606-6-44

Cite this

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title = "Transcriptional regulation and its misregulation in Alzheimer's disease",

abstract = "Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by loss of memory and cognitive function. A key neuropathological event in AD is the accumulation of amyloid-β (Aβ) peptide. The production and clearance of Aβ in the brain are regulated by a large group of genes. The expression levels of these genes must be fine-tuned in the brain to keep Aβ at a balanced amount under physiological condition. Misregulation of AD genes has been found to either increase AD risk or accelerate the disease progression. In recent years, important progress has been made in uncovering the regulatory elements and transcriptional factors that guide the expression of these genes. In this review, we describe the mechanisms of transcriptional regulation for the known AD genes and the misregualtion that leads to AD susceptibility.",

keywords = "Alzheimer's disease, Amyloid-β, Polymorphism, Transcription factors, Transcriptional regulatory element",

author = "Chen, {Xiao Fen} and Zhang, {Yun Wu} and Huaxi Xu and Guojun Bu",

note = "Funding Information: Research by the authors is supported by a grant (81370459) from the National Natural Science Foundation of China. We also wish to sincerely thank Melissa Wren for language editing of this manuscript.",

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T1 - Transcriptional regulation and its misregulation in Alzheimer's disease

AU - Chen, Xiao Fen

AU - Zhang, Yun Wu

AU - Xu, Huaxi

AU - Bu, Guojun

N1 - Funding Information: Research by the authors is supported by a grant (81370459) from the National Natural Science Foundation of China. We also wish to sincerely thank Melissa Wren for language editing of this manuscript.

PY - 2013

Y1 - 2013

N2 - Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by loss of memory and cognitive function. A key neuropathological event in AD is the accumulation of amyloid-β (Aβ) peptide. The production and clearance of Aβ in the brain are regulated by a large group of genes. The expression levels of these genes must be fine-tuned in the brain to keep Aβ at a balanced amount under physiological condition. Misregulation of AD genes has been found to either increase AD risk or accelerate the disease progression. In recent years, important progress has been made in uncovering the regulatory elements and transcriptional factors that guide the expression of these genes. In this review, we describe the mechanisms of transcriptional regulation for the known AD genes and the misregualtion that leads to AD susceptibility.

AB - Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by loss of memory and cognitive function. A key neuropathological event in AD is the accumulation of amyloid-β (Aβ) peptide. The production and clearance of Aβ in the brain are regulated by a large group of genes. The expression levels of these genes must be fine-tuned in the brain to keep Aβ at a balanced amount under physiological condition. Misregulation of AD genes has been found to either increase AD risk or accelerate the disease progression. In recent years, important progress has been made in uncovering the regulatory elements and transcriptional factors that guide the expression of these genes. In this review, we describe the mechanisms of transcriptional regulation for the known AD genes and the misregualtion that leads to AD susceptibility.

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KW - Amyloid-β

KW - Polymorphism

KW - Transcription factors

KW - Transcriptional regulatory element

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Transcriptional regulation and its misregulation in Alzheimer's disease

Abstract

Keywords

ASJC Scopus subject areas

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