Abstract
Evidence is accruing that the architectural organization of nucleic acids and regulatory proteins within the cell nucleus support functional interrelationships between nuclear structure and gene expression. The punctate distribution of several transcription factors has provided several paradigms for pursuing mechanisms that direct these regulatory proteins to subnuclear sites where gene activation or suppression occurs. Sequences that are necessary and sufficient to direct regulatory proteins to transcriptionally active nuclear domains have been identified. Mutations that disrupt intranuclear targeting signals lead to modified subnuclear distribution of transcription factors and aberrant expression in tumor cells.
Original language | English (US) |
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Pages (from-to) | 24-31 |
Number of pages | 8 |
Journal | Journal of cellular biochemistry |
Volume | 76 |
Issue number | SUPPL. 32/33 |
DOIs | |
State | Published - 1999 |
Keywords
- AML/CBFA
- Gene expression
- Intranuclear targeting
- Subnuclear domains
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology