Transcriptional control within the three-dimensional context of nuclear architecture

Requirements for boundaries and direction

Gary S. Stein, Andre J van Wijnen, Janet L. Stein, Jane B. Lian, Sandra McNeil, Shirvvin M. Pockwinse

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Evidence is accruing that the architectural organization of nucleic acids and regulatory proteins within the cell nucleus support functional interrelationships between nuclear structure and gene expression. The punctate distribution of several transcription factors has provided several paradigms for pursuing mechanisms that direct these regulatory proteins to subnuclear sites where gene activation or suppression occurs. Sequences that are necessary and sufficient to direct regulatory proteins to transcriptionally active nuclear domains have been identified. Mutations that disrupt intranuclear targeting signals lead to modified subnuclear distribution of transcription factors and aberrant expression in tumor cells.

Original languageEnglish (US)
Pages (from-to)24-31
Number of pages8
JournalJournal of Cellular Biochemistry
Volume76
Issue numberSUPPL. 32/33
StatePublished - 1999
Externally publishedYes

Fingerprint

Transcription Factors
Cells
Proteins
Cell Nucleus
Gene expression
Nucleic Acids
Transcriptional Activation
Tumors
Genes
Chemical activation
Gene Expression
Mutation
Direction compound
Neoplasms

Keywords

  • AML/CBFA
  • Gene expression
  • Intranuclear targeting
  • Subnuclear domains

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

Cite this

Stein, G. S., van Wijnen, A. J., Stein, J. L., Lian, J. B., McNeil, S., & Pockwinse, S. M. (1999). Transcriptional control within the three-dimensional context of nuclear architecture: Requirements for boundaries and direction. Journal of Cellular Biochemistry, 76(SUPPL. 32/33), 24-31.

Transcriptional control within the three-dimensional context of nuclear architecture : Requirements for boundaries and direction. / Stein, Gary S.; van Wijnen, Andre J; Stein, Janet L.; Lian, Jane B.; McNeil, Sandra; Pockwinse, Shirvvin M.

In: Journal of Cellular Biochemistry, Vol. 76, No. SUPPL. 32/33, 1999, p. 24-31.

Research output: Contribution to journalArticle

Stein, GS, van Wijnen, AJ, Stein, JL, Lian, JB, McNeil, S & Pockwinse, SM 1999, 'Transcriptional control within the three-dimensional context of nuclear architecture: Requirements for boundaries and direction', Journal of Cellular Biochemistry, vol. 76, no. SUPPL. 32/33, pp. 24-31.
Stein, Gary S. ; van Wijnen, Andre J ; Stein, Janet L. ; Lian, Jane B. ; McNeil, Sandra ; Pockwinse, Shirvvin M. / Transcriptional control within the three-dimensional context of nuclear architecture : Requirements for boundaries and direction. In: Journal of Cellular Biochemistry. 1999 ; Vol. 76, No. SUPPL. 32/33. pp. 24-31.
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