Abstract
Evidence is accruing that the architectural organization of nucleic acids and regulatory proteins within the cell nucleus support functional interrelationships between nuclear structure and gene expression. The punctate distribution of several transcription factors has provided several paradigms for pursuing mechanisms that direct these regulatory proteins to subnuclear sites where gene activation or suppression occurs. Sequences that are necessary and sufficient to direct regulatory proteins to transcriptionally active nuclear domains have been identified. Mutations that disrupt intranuclear targeting signals lead to modified subnuclear distribution of transcription factors and aberrant expression in tumor cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 24-31 |
| Number of pages | 8 |
| Journal | Journal of Cellular Biochemistry |
| Volume | 76 |
| Issue number | SUPPL. 32/33 |
| State | Published - 1999 |
| Externally published | Yes |
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Keywords
- AML/CBFA
- Gene expression
- Intranuclear targeting
- Subnuclear domains
ASJC Scopus subject areas
- Biochemistry
- Cell Biology
Cite this
Transcriptional control within the three-dimensional context of nuclear architecture : Requirements for boundaries and direction. / Stein, Gary S.; van Wijnen, Andre J; Stein, Janet L.; Lian, Jane B.; McNeil, Sandra; Pockwinse, Shirvvin M.
In: Journal of Cellular Biochemistry, Vol. 76, No. SUPPL. 32/33, 1999, p. 24-31.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Transcriptional control within the three-dimensional context of nuclear architecture
T2 - Requirements for boundaries and direction
AU - Stein, Gary S.
AU - van Wijnen, Andre J
AU - Stein, Janet L.
AU - Lian, Jane B.
AU - McNeil, Sandra
AU - Pockwinse, Shirvvin M.
PY - 1999
Y1 - 1999
N2 - Evidence is accruing that the architectural organization of nucleic acids and regulatory proteins within the cell nucleus support functional interrelationships between nuclear structure and gene expression. The punctate distribution of several transcription factors has provided several paradigms for pursuing mechanisms that direct these regulatory proteins to subnuclear sites where gene activation or suppression occurs. Sequences that are necessary and sufficient to direct regulatory proteins to transcriptionally active nuclear domains have been identified. Mutations that disrupt intranuclear targeting signals lead to modified subnuclear distribution of transcription factors and aberrant expression in tumor cells.
AB - Evidence is accruing that the architectural organization of nucleic acids and regulatory proteins within the cell nucleus support functional interrelationships between nuclear structure and gene expression. The punctate distribution of several transcription factors has provided several paradigms for pursuing mechanisms that direct these regulatory proteins to subnuclear sites where gene activation or suppression occurs. Sequences that are necessary and sufficient to direct regulatory proteins to transcriptionally active nuclear domains have been identified. Mutations that disrupt intranuclear targeting signals lead to modified subnuclear distribution of transcription factors and aberrant expression in tumor cells.
KW - AML/CBFA
KW - Gene expression
KW - Intranuclear targeting
KW - Subnuclear domains
UR - http://www.scopus.com/inward/record.url?scp=0033251386&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033251386&partnerID=8YFLogxK
M3 - Article
VL - 76
SP - 24
EP - 31
JO - Journal of Cellular Biochemistry
JF - Journal of Cellular Biochemistry
SN - 0730-2312
IS - SUPPL. 32/33
ER -