Transcriptional control within the three-dimensional context of nuclear architecture: Requirements for boundaries and direction

Gary S. Stein, André J. Van Wijnen, Janet L. Stein, Jane B. Lian, Sandra McNeil, Shirvvin M. Pockwinse

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Evidence is accruing that the architectural organization of nucleic acids and regulatory proteins within the cell nucleus support functional interrelationships between nuclear structure and gene expression. The punctate distribution of several transcription factors has provided several paradigms for pursuing mechanisms that direct these regulatory proteins to subnuclear sites where gene activation or suppression occurs. Sequences that are necessary and sufficient to direct regulatory proteins to transcriptionally active nuclear domains have been identified. Mutations that disrupt intranuclear targeting signals lead to modified subnuclear distribution of transcription factors and aberrant expression in tumor cells.

Original languageEnglish (US)
Pages (from-to)24-31
Number of pages8
JournalJournal of cellular biochemistry
Volume76
Issue numberSUPPL. 32/33
StatePublished - Dec 1 1999

Keywords

  • AML/CBFA
  • Gene expression
  • Intranuclear targeting
  • Subnuclear domains

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Transcriptional control within the three-dimensional context of nuclear architecture: Requirements for boundaries and direction'. Together they form a unique fingerprint.

  • Cite this

    Stein, G. S., Van Wijnen, A. J., Stein, J. L., Lian, J. B., McNeil, S., & Pockwinse, S. M. (1999). Transcriptional control within the three-dimensional context of nuclear architecture: Requirements for boundaries and direction. Journal of cellular biochemistry, 76(SUPPL. 32/33), 24-31.