Transcriptional control of gene expression in pancreatic cancer: From sequence-specific transcription factors to nuclear architecture

Volker Ellenrieder; Martin E. Fernandez-Zapico

doi:10.1007/s12029-011-9254-4

Transcriptional control of gene expression in pancreatic cancer: From sequence-specific transcription factors to nuclear architecture

Volker Ellenrieder, Martin E. Fernandez-Zapico

Oncology

Research output: Contribution to journal › Article › peer-review

Abstract

Transcription plays a central role in the regulation of gene expression during neoplastic transformation in different tissues. Using this nuclear process as a common topic in this special issue of the Journal of Gastrointestinal Cancer we have covered with five review articles key aspects of gene transcription and its impact in pancreatic carcinogenesis. We are confident that the knowledge included in these review articles will help understand the contribution of this molecular event to the pathogenesis of this devastating disease and serve as foundation for the development of new therapeutic tools.

Original language	English (US)
Pages (from-to)	73-75
Number of pages	3
Journal	Journal of gastrointestinal cancer
Volume	42
Issue number	2
DOIs	https://doi.org/10.1007/s12029-011-9254-4
State	Published - Jun 2011

Keywords

Chromatin
Gene expression
Nucleus
Pancreatic cancer
Transcription

ASJC Scopus subject areas

Oncology
Gastroenterology

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10.1007/s12029-011-9254-4

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title = "Transcriptional control of gene expression in pancreatic cancer: From sequence-specific transcription factors to nuclear architecture",

abstract = "Transcription plays a central role in the regulation of gene expression during neoplastic transformation in different tissues. Using this nuclear process as a common topic in this special issue of the Journal of Gastrointestinal Cancer we have covered with five review articles key aspects of gene transcription and its impact in pancreatic carcinogenesis. We are confident that the knowledge included in these review articles will help understand the contribution of this molecular event to the pathogenesis of this devastating disease and serve as foundation for the development of new therapeutic tools.",

keywords = "Chromatin, Gene expression, Nucleus, Pancreatic cancer, Transcription",

author = "Volker Ellenrieder and Fernandez-Zapico, {Martin E.}",

note = "Funding Information: Acknowledgement V.E. is supported by the Deutsche Forschungs-gemeinschaft (DFG, SFB-TR17), the LOEWE-Schwerpunkt “Tumor and Inflammation,” and the Max Eder programme of the German Cancer Research Foundation (Deutsche Krebshilfe, 70-3022-El I). M. E.F.-Z. is supported by the Division of Oncology Research, Mayo Clinic Cancer Center, CA136526, Mayo Clinic Pancreatic SPORE P50 CA102701, and Mayo Clinic Center for Cell Signaling in Gastroenterology NIDDK P30 DK084567.",

year = "2011",

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doi = "10.1007/s12029-011-9254-4",

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N2 - Transcription plays a central role in the regulation of gene expression during neoplastic transformation in different tissues. Using this nuclear process as a common topic in this special issue of the Journal of Gastrointestinal Cancer we have covered with five review articles key aspects of gene transcription and its impact in pancreatic carcinogenesis. We are confident that the knowledge included in these review articles will help understand the contribution of this molecular event to the pathogenesis of this devastating disease and serve as foundation for the development of new therapeutic tools.

AB - Transcription plays a central role in the regulation of gene expression during neoplastic transformation in different tissues. Using this nuclear process as a common topic in this special issue of the Journal of Gastrointestinal Cancer we have covered with five review articles key aspects of gene transcription and its impact in pancreatic carcinogenesis. We are confident that the knowledge included in these review articles will help understand the contribution of this molecular event to the pathogenesis of this devastating disease and serve as foundation for the development of new therapeutic tools.

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KW - Gene expression

KW - Nucleus

KW - Pancreatic cancer

KW - Transcription

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Transcriptional control of gene expression in pancreatic cancer: From sequence-specific transcription factors to nuclear architecture

Abstract

Keywords

ASJC Scopus subject areas

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