Transcriptional control of cell cycle progression: The histone gene is a paradigm for the G1/S phase and proliferation/differentiation transitions

Gary S. Stein, Janet L. Stein, André J. Van Wijnen, Jane B. Lian

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

The histone gene is a paradigm for transcriptional control at the G1/S phase transition point in the cell cycle. The histone gene promoter provides a blueprint for integration of regulatory signals which mediate responsiveness to factors controlling competency for cell cycle progression at the initiation of DNA replication. The downregulation of proliferation at the onset of differentiation is accompanied by and functionally linked to modifications in protein-DNA and protein-protein interactions at histone gene promoter regulatory elements. Chromatin structure, nucleosome organization and gene-nuclear matrix interactions facilitate crosstalk between regulatory sequences and targeting of transcription factors to cognate binding domains.

Original languageEnglish (US)
Pages (from-to)41-49
Number of pages9
JournalCell biology international
Volume20
Issue number1
DOIs
StatePublished - Jan 1996

Keywords

  • Cell cycle
  • Differentiation
  • Growth control
  • Histone genes
  • Proliferation
  • Transcription

ASJC Scopus subject areas

  • Cell Biology

Fingerprint Dive into the research topics of 'Transcriptional control of cell cycle progression: The histone gene is a paradigm for the G1/S phase and proliferation/differentiation transitions'. Together they form a unique fingerprint.

  • Cite this