Transcription-factor-mediated epigenetic control of cell fate and lineage commitment

Gary S. Stein, Sayyed K. Zaidi, Janet L. Stein, Jane B. Lian, Andre J. Van Wijnen, Martin Montecino, Daniel W. Young, Amjad Javed, Jitesh Pratap, Je Yong Choi, Syed A. Ali, Sandhya Pande, Mohammad Q. Hassan

Research output: Contribution to journalReview article

19 Scopus citations

Abstract

Epigenetic control is required to maintain competency for the activation and suppression of genes during cell division. The association between regulatory proteins and target gene loci during mitosis is a parameter of the epigenetic control that sustains the transcriptional regulatory machinery that perpetuates gene-expression signatures in progeny cells. The mitotic retention of phenotypic regulatory factors with cell cycle, cell fate, and tissue-specific genes supports the coordinated control that governs the proliferation and differentiation of cell fate and lineage commitment.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalBiochemistry and Cell Biology
Volume87
Issue number1
DOIs
StatePublished - Feb 2009

Keywords

  • Cell cycle
  • Chromatin
  • Gene expression
  • Intranuclear trafficking
  • Nuclear microenvironment
  • Runx

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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  • Cite this

    Stein, G. S., Zaidi, S. K., Stein, J. L., Lian, J. B., Van Wijnen, A. J., Montecino, M., Young, D. W., Javed, A., Pratap, J., Choi, J. Y., Ali, S. A., Pande, S., & Hassan, M. Q. (2009). Transcription-factor-mediated epigenetic control of cell fate and lineage commitment. Biochemistry and Cell Biology, 87(1), 1-6. https://doi.org/10.1139/O08-094