Transcription-factor-mediated epigenetic control of cell fate and lineage commitment

Gary S. Stein; Sayyed K. Zaidi; Janet L. Stein; Jane B. Lian; Andre J. Van Wijnen; Martin Montecino; Daniel W. Young; Amjad Javed; Jitesh Pratap; Je Yong Choi; Syed A. Ali; Sandhya Pande; Mohammad Q. Hassan

doi:10.1139/O08-094

Transcription-factor-mediated epigenetic control of cell fate and lineage commitment

Gary S. Stein, Sayyed K. Zaidi, Janet L. Stein, Jane B. Lian, Andre J. Van Wijnen, Martin Montecino, Daniel W. Young, Amjad Javed, Jitesh Pratap, Je Yong Choi, Syed A. Ali, Sandhya Pande, Mohammad Q. Hassan

Orthopedic Surgery

Research output: Contribution to journal › Review article › peer-review

19 Scopus citations

Abstract

Epigenetic control is required to maintain competency for the activation and suppression of genes during cell division. The association between regulatory proteins and target gene loci during mitosis is a parameter of the epigenetic control that sustains the transcriptional regulatory machinery that perpetuates gene-expression signatures in progeny cells. The mitotic retention of phenotypic regulatory factors with cell cycle, cell fate, and tissue-specific genes supports the coordinated control that governs the proliferation and differentiation of cell fate and lineage commitment.

Original language	English (US)
Pages (from-to)	1-6
Number of pages	6
Journal	Biochemistry and Cell Biology
Volume	87
Issue number	1
DOIs	https://doi.org/10.1139/O08-094
State	Published - Feb 2009

Keywords

Cell cycle
Chromatin
Gene expression
Intranuclear trafficking
Nuclear microenvironment
Runx

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1139/O08-094

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title = "Transcription-factor-mediated epigenetic control of cell fate and lineage commitment",

abstract = "Epigenetic control is required to maintain competency for the activation and suppression of genes during cell division. The association between regulatory proteins and target gene loci during mitosis is a parameter of the epigenetic control that sustains the transcriptional regulatory machinery that perpetuates gene-expression signatures in progeny cells. The mitotic retention of phenotypic regulatory factors with cell cycle, cell fate, and tissue-specific genes supports the coordinated control that governs the proliferation and differentiation of cell fate and lineage commitment.",

keywords = "Cell cycle, Chromatin, Gene expression, Intranuclear trafficking, Nuclear microenvironment, Runx",

author = "Stein, {Gary S.} and Zaidi, {Sayyed K.} and Stein, {Janet L.} and Lian, {Jane B.} and {Van Wijnen}, {Andre J.} and Martin Montecino and Young, {Daniel W.} and Amjad Javed and Jitesh Pratap and Choi, {Je Yong} and Ali, {Syed A.} and Sandhya Pande and Hassan, {Mohammad Q.}",

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doi = "10.1139/O08-094",

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T1 - Transcription-factor-mediated epigenetic control of cell fate and lineage commitment

AU - Stein, Gary S.

AU - Zaidi, Sayyed K.

AU - Stein, Janet L.

AU - Lian, Jane B.

AU - Van Wijnen, Andre J.

AU - Montecino, Martin

AU - Young, Daniel W.

AU - Javed, Amjad

AU - Pratap, Jitesh

AU - Choi, Je Yong

AU - Ali, Syed A.

AU - Pande, Sandhya

AU - Hassan, Mohammad Q.

PY - 2009/2

Y1 - 2009/2

N2 - Epigenetic control is required to maintain competency for the activation and suppression of genes during cell division. The association between regulatory proteins and target gene loci during mitosis is a parameter of the epigenetic control that sustains the transcriptional regulatory machinery that perpetuates gene-expression signatures in progeny cells. The mitotic retention of phenotypic regulatory factors with cell cycle, cell fate, and tissue-specific genes supports the coordinated control that governs the proliferation and differentiation of cell fate and lineage commitment.

AB - Epigenetic control is required to maintain competency for the activation and suppression of genes during cell division. The association between regulatory proteins and target gene loci during mitosis is a parameter of the epigenetic control that sustains the transcriptional regulatory machinery that perpetuates gene-expression signatures in progeny cells. The mitotic retention of phenotypic regulatory factors with cell cycle, cell fate, and tissue-specific genes supports the coordinated control that governs the proliferation and differentiation of cell fate and lineage commitment.

KW - Cell cycle

KW - Chromatin

KW - Gene expression

KW - Intranuclear trafficking

KW - Nuclear microenvironment

KW - Runx

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M3 - Review article

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JO - Biochemistry and Cell Biology

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Transcription-factor-mediated epigenetic control of cell fate and lineage commitment

Abstract

Keywords

ASJC Scopus subject areas

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