Transcranial magnetic stimulation potentiates glutamatergic neurotransmission in depressed adolescents

Paul E Croarkin, Paul A. Nakonezny, Christopher A. Wall, Lauren L. Murphy, Shirlene M. Sampson, Mark A Frye, John D Port

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Abnormalities in glutamate neurotransmission may have a role in the pathophysiology of adolescent depression. The present pilot study examined changes in cortical glutamine/glutamate ratios in depressed adolescents receiving high-frequency repetitive transcranial magnetic stimulation. Ten adolescents with treatment-refractory major depressive disorder received up to 30 sessions of 10-Hz repetitive transcranial magnetic stimulation at 120% motor threshold with 3000 pulses per session applied to the left dorsolateral prefrontal cortex. Baseline, posttreatment, and 6-month follow-up proton magnetic resonance spectroscopy scans of the anterior cingulate cortex and left dorsolateral prefrontal cortex were collected at 3 T with 8-cm3 voxels. Glutamate metabolites were quantified with 2 distinct proton magnetic resonance spectroscopy sequences in each brain region. After repetitive transcranial magnetic stimulation and at 6 months of follow-up, glutamine/glutamate ratios increased in the anterior cingulate cortex and left dorsolateral prefrontal cortex with both measurements. The increase in the glutamine/glutamate ratio reached statistical significance with the TE-optimized PRESS sequence in the anterior cingulate cortex. Glutamine/glutamate ratios increased in conjunction with depressive symptom improvement. This reached statistical significance with the TE-optimized PRESS sequence in the left dorsolateral prefrontal cortex. High-frequency repetitive transcranial magnetic stimulation applied to the left dorsolateral prefrontal cortex may modulate glutamate neurochemistry in depressed adolescents.

Original languageEnglish (US)
Pages (from-to)25-33
Number of pages9
JournalPsychiatry Research - Neuroimaging
Volume247
DOIs
StatePublished - Jan 30 2016

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Transcranial Magnetic Stimulation
Synaptic Transmission
Glutamic Acid
Prefrontal Cortex
Glutamine
Gyrus Cinguli
Depression
Neurochemistry
Major Depressive Disorder
Brain

Keywords

  • Adolescent depression
  • Glutamate
  • Glutamine
  • Proton magnetic resonance spectroscopy
  • Repetitive transcranial magnetic stimulation

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Radiology Nuclear Medicine and imaging
  • Neuroscience (miscellaneous)

Cite this

Transcranial magnetic stimulation potentiates glutamatergic neurotransmission in depressed adolescents. / Croarkin, Paul E; Nakonezny, Paul A.; Wall, Christopher A.; Murphy, Lauren L.; Sampson, Shirlene M.; Frye, Mark A; Port, John D.

In: Psychiatry Research - Neuroimaging, Vol. 247, 30.01.2016, p. 25-33.

Research output: Contribution to journalArticle

Croarkin, Paul E ; Nakonezny, Paul A. ; Wall, Christopher A. ; Murphy, Lauren L. ; Sampson, Shirlene M. ; Frye, Mark A ; Port, John D. / Transcranial magnetic stimulation potentiates glutamatergic neurotransmission in depressed adolescents. In: Psychiatry Research - Neuroimaging. 2016 ; Vol. 247. pp. 25-33.
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