Transcranial doppler evaluation in takayasu arteritis with oculo-cerebrovascular complications

Michael E. Christiansen, Cumara B. O'Carroll, Gyanendra Kumar, Brandon Larsen, Oana M. Dumitrascu

Research output: Contribution to journalArticle

Abstract

Introduction: Takayasu arteritis is a large-vessel vasculitis that may cause oculo-cerebral ischemia. We report a patient with visual loss as initial manifestation, and discuss transcranial Doppler (TCD) findings before and after surgical revascularization. Case Description: A 19-year-old female developed episodes of transient positional right vision loss, progressing to permanent right vision loss and bright light-induced left amaurosis. Examination demonstrated subclavian bruits, palpable epigastrium aortic pulsation, faint radial pulses, right retinal pallor, arteriolar narrowing, and bilateral boxcarring. Head and neck computed tomography angiogram demonstrated left subclavian origin and right common carotid artery occlusion, and severe innominate and left common carotid artery stenosis. TCD demonstrated right ophthalmic artery flow reversal and nonpulsatile waveforms with dampened spectra in the right anterior circulation. Corticosteroids, methotrexate, infliximab, and dual-antiplatelet therapy were initiated. Eleven weeks later, the patient underwent ascending aortic aneurysm repair and bilateral carotid artery bypass with an aortic graft. Pathology was consistent with chronic active Takayasu arteritis. Two weeks postoperatively, left eye visual symptoms resolved; right visual loss persisted. Postoperative TCD showed marked improvement in cerebral perfusion. Conclusions: Retinal ischemia in young women should prompt emergent inflammatory and systemic vascular evaluation. In our subject, prolonged right retinal ischemia had dismal prognosis despite carotid-aortic revascularization, whereas left retinal boxcarring reversed. Surgical revascularization is recommended for severely symptomatic oculo-cerebrovascular disease, once inflammation is better controlled with immunosuppressive therapy. TCD documented the presence and monitored the subsequent resolution of blood flow changes causing retinal and brain hypoxia.

Original languageEnglish (US)
Pages (from-to)17-21
Number of pages5
JournalNeurologist
Volume24
Issue number1
DOIs
StatePublished - Jan 1 2019

Fingerprint

Takayasu Arteritis
Ischemia
Ophthalmic Artery
Pallor
Cerebrovascular Disorders
Brain Hypoxia
Aortic Aneurysm
Carotid Stenosis
Common Carotid Artery
Blindness
Immunosuppressive Agents
Vasculitis
Brain Ischemia
Carotid Arteries
Methotrexate
Blood Vessels
Angiography
Adrenal Cortex Hormones
Neck
Perfusion

Keywords

  • retina
  • revascularization
  • Takayasu arteritis
  • transcranial Doppler
  • visual loss

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Transcranial doppler evaluation in takayasu arteritis with oculo-cerebrovascular complications. / Christiansen, Michael E.; O'Carroll, Cumara B.; Kumar, Gyanendra; Larsen, Brandon; Dumitrascu, Oana M.

In: Neurologist, Vol. 24, No. 1, 01.01.2019, p. 17-21.

Research output: Contribution to journalArticle

Christiansen, Michael E. ; O'Carroll, Cumara B. ; Kumar, Gyanendra ; Larsen, Brandon ; Dumitrascu, Oana M. / Transcranial doppler evaluation in takayasu arteritis with oculo-cerebrovascular complications. In: Neurologist. 2019 ; Vol. 24, No. 1. pp. 17-21.
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