Transcranial direct current stimulation: Considerations for research in adolescent depression

Jonathan C. Lee, Charles P. Lewis, Zafiris J. Daskalakis, Paul E Croarkin

Research output: Contribution to journalShort survey

5 Citations (Scopus)

Abstract

Adolescent depression is a prevalent disorder with substantial morbidity and mortality. Current treatment interventions do not target relevant pathophysiology and are frequently ineffective, thereby leading to a substantial burden for individuals, families, and society. During adolescence, the prefrontal cortex undergoes extensive structural and functional changes. Recent work suggests that frontolimbic development in depressed adolescents is delayed or aberrant. The judicious application of non-invasive brain stimulation techniques to the prefrontal cortex may present a promising opportunity for durable interventions in adolescent depression. Transcranial direct current stimulation (tDCS) applies a low-intensity, continuous current that alters cortical excitability. While this modality does not elicit action potentials, it is thought to manipulate neuronal activity and neuroplasticity. Specifically, tDCS may modulate N-methyl-d-aspartate receptors and L-type voltage-gated calcium channels and effect changes through long-term potentiation or long-term depression-like mechanisms. This mini-review considers the neurobiological rationale for developing tDCS protocols in adolescent depression, reviews existing work in adult mood disorders, surveys the existing tDCS literature in adolescent populations, reviews safety studies, and discusses distinct ethical considerations in work with adolescents.

Original languageEnglish (US)
Article number91
JournalFrontiers in Psychiatry
Volume8
Issue numberJUN
DOIs
StatePublished - Jun 7 2017

Fingerprint

Depression
Research
Prefrontal Cortex
Neuronal Plasticity
Long-Term Potentiation
Calcium Channels
Transcranial Direct Current Stimulation
Mood Disorders
Action Potentials
Morbidity
Safety
Mortality
Brain
Population
Therapeutics

Keywords

  • Adolescent depression
  • Neurostimulation
  • Non-invasive brain stimulation
  • Transcranial current stimulation
  • Transcranial direct current stimulation

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Transcranial direct current stimulation : Considerations for research in adolescent depression. / Lee, Jonathan C.; Lewis, Charles P.; Daskalakis, Zafiris J.; Croarkin, Paul E.

In: Frontiers in Psychiatry, Vol. 8, No. JUN, 91, 07.06.2017.

Research output: Contribution to journalShort survey

Lee, Jonathan C. ; Lewis, Charles P. ; Daskalakis, Zafiris J. ; Croarkin, Paul E. / Transcranial direct current stimulation : Considerations for research in adolescent depression. In: Frontiers in Psychiatry. 2017 ; Vol. 8, No. JUN.
@article{d803b67a55254308ba8033745eeb4935,
title = "Transcranial direct current stimulation: Considerations for research in adolescent depression",
abstract = "Adolescent depression is a prevalent disorder with substantial morbidity and mortality. Current treatment interventions do not target relevant pathophysiology and are frequently ineffective, thereby leading to a substantial burden for individuals, families, and society. During adolescence, the prefrontal cortex undergoes extensive structural and functional changes. Recent work suggests that frontolimbic development in depressed adolescents is delayed or aberrant. The judicious application of non-invasive brain stimulation techniques to the prefrontal cortex may present a promising opportunity for durable interventions in adolescent depression. Transcranial direct current stimulation (tDCS) applies a low-intensity, continuous current that alters cortical excitability. While this modality does not elicit action potentials, it is thought to manipulate neuronal activity and neuroplasticity. Specifically, tDCS may modulate N-methyl-d-aspartate receptors and L-type voltage-gated calcium channels and effect changes through long-term potentiation or long-term depression-like mechanisms. This mini-review considers the neurobiological rationale for developing tDCS protocols in adolescent depression, reviews existing work in adult mood disorders, surveys the existing tDCS literature in adolescent populations, reviews safety studies, and discusses distinct ethical considerations in work with adolescents.",
keywords = "Adolescent depression, Neurostimulation, Non-invasive brain stimulation, Transcranial current stimulation, Transcranial direct current stimulation",
author = "Lee, {Jonathan C.} and Lewis, {Charles P.} and Daskalakis, {Zafiris J.} and Croarkin, {Paul E}",
year = "2017",
month = "6",
day = "7",
doi = "10.3389/fpsyt.2017.00091",
language = "English (US)",
volume = "8",
journal = "Frontiers in Psychiatry",
issn = "1664-0640",
publisher = "Frontiers Research Foundation",
number = "JUN",

}

TY - JOUR

T1 - Transcranial direct current stimulation

T2 - Considerations for research in adolescent depression

AU - Lee, Jonathan C.

AU - Lewis, Charles P.

AU - Daskalakis, Zafiris J.

AU - Croarkin, Paul E

PY - 2017/6/7

Y1 - 2017/6/7

N2 - Adolescent depression is a prevalent disorder with substantial morbidity and mortality. Current treatment interventions do not target relevant pathophysiology and are frequently ineffective, thereby leading to a substantial burden for individuals, families, and society. During adolescence, the prefrontal cortex undergoes extensive structural and functional changes. Recent work suggests that frontolimbic development in depressed adolescents is delayed or aberrant. The judicious application of non-invasive brain stimulation techniques to the prefrontal cortex may present a promising opportunity for durable interventions in adolescent depression. Transcranial direct current stimulation (tDCS) applies a low-intensity, continuous current that alters cortical excitability. While this modality does not elicit action potentials, it is thought to manipulate neuronal activity and neuroplasticity. Specifically, tDCS may modulate N-methyl-d-aspartate receptors and L-type voltage-gated calcium channels and effect changes through long-term potentiation or long-term depression-like mechanisms. This mini-review considers the neurobiological rationale for developing tDCS protocols in adolescent depression, reviews existing work in adult mood disorders, surveys the existing tDCS literature in adolescent populations, reviews safety studies, and discusses distinct ethical considerations in work with adolescents.

AB - Adolescent depression is a prevalent disorder with substantial morbidity and mortality. Current treatment interventions do not target relevant pathophysiology and are frequently ineffective, thereby leading to a substantial burden for individuals, families, and society. During adolescence, the prefrontal cortex undergoes extensive structural and functional changes. Recent work suggests that frontolimbic development in depressed adolescents is delayed or aberrant. The judicious application of non-invasive brain stimulation techniques to the prefrontal cortex may present a promising opportunity for durable interventions in adolescent depression. Transcranial direct current stimulation (tDCS) applies a low-intensity, continuous current that alters cortical excitability. While this modality does not elicit action potentials, it is thought to manipulate neuronal activity and neuroplasticity. Specifically, tDCS may modulate N-methyl-d-aspartate receptors and L-type voltage-gated calcium channels and effect changes through long-term potentiation or long-term depression-like mechanisms. This mini-review considers the neurobiological rationale for developing tDCS protocols in adolescent depression, reviews existing work in adult mood disorders, surveys the existing tDCS literature in adolescent populations, reviews safety studies, and discusses distinct ethical considerations in work with adolescents.

KW - Adolescent depression

KW - Neurostimulation

KW - Non-invasive brain stimulation

KW - Transcranial current stimulation

KW - Transcranial direct current stimulation

UR - http://www.scopus.com/inward/record.url?scp=85020493184&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85020493184&partnerID=8YFLogxK

U2 - 10.3389/fpsyt.2017.00091

DO - 10.3389/fpsyt.2017.00091

M3 - Short survey

AN - SCOPUS:85020493184

VL - 8

JO - Frontiers in Psychiatry

JF - Frontiers in Psychiatry

SN - 1664-0640

IS - JUN

M1 - 91

ER -