Transcolonic peritoneoscopy by using submucosal endoscopy with mucosal flap for the detection of peritoneal bead targeting in the porcine survival model: A feasibility and effectiveness study

Kohei Takizawa, Rushin Brahmbhatt, Mary A. Knipschield, Juliane Bingener, Christopher J. Gostout

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Background Staging peritoneoscopy is typically done by laparoscopy in the operating room. Natural orifice transluminal endoscopic surgery peritoneoscopy is an appealing alternative to the current approach. Transcolonic submucosal endoscopy with mucosal flap (SEMF) may provide natural orifice transluminal endoscopic surgery peritoneoscopy. Objective The aim was to verify the feasibility and safety of transcolonic peritoneoscopy with SEMF (TCPS) in a porcine survival model. Design Survival study. Setting Animal research unit. Intervention Seven target beads were placed in the peritoneal cavity by laparoscopy in each of 6 animals, and TCPS was performed to identify and touch beads to simulate biopsy. Animals were euthanized after 1 week, at which time, laparotomy was performed and the SEMF site was resected for histological analysis. Main Outcome Measurements The number of beads identified and touched during peritoneoscopy, rate of successful completion of TCPS, procedure time, mortality equivalent 1 week after TCPS, adverse event rate, histological assessment of SEMF site. Results All 7 beads in all 6 pigs were identified and touched during TCPS. The success rate of TCP was 100%. No major adverse events occurred during the procedure. The median procedure times for the creation of a submucosal tunnel, peritoneoscopy, closure of mucosal incision, and entire procedure were 19.5, 17, 9.5, and 45 minutes, respectively. All pigs survived until euthanasia, and there was no evidence of peritonitis or severe infection. Limitations Animal study, single endoscopist, small sample size. Conclusion Results of this study indicate that TCPS is feasible and safe in a porcine survival model.

Original languageEnglish (US)
Pages (from-to)127-134
Number of pages8
JournalGastrointestinal endoscopy
Volume79
Issue number1
DOIs
StatePublished - Jan 1 2014

Keywords

  • ESD
  • NOTES
  • SEMF
  • SFC
  • TCPS
  • endoscopic submucosal dissection
  • natural orifice transluminal endoscopic surgery
  • submucosal endoscopy with mucosal flap
  • submucosal fluid cushion
  • transcolonic peritoneoscopy with submucosal endoscopy with mucosal flap

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology

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