Transbronchial Cryobiopsies for the Diagnosis of Diffuse Parenchymal Lung Diseases

Expert Statement from the Cryobiopsy Working Group on Safety and Utility and a Call for Standardization of the Procedure

Jürgen Hetzel, Fabien Maldonado, Claudia Ravaglia, Athol U. Wells, Thomas V. Colby, Sara Tomassetti, Jay H Ryu, Oren Fruchter, Sara Piciucchi, Alessandra Dubini, Alberto Cavazza, Marco Chilosi, Nicola Sverzellati, Dominique Valeyre, Dimitri Leduc, Simon L.F. Walsh, Stefano Gasparini, Martin Hetzel, Lars Hagmeyer, Maik Haentschel & 9 others Ralf Eberhardt, Kaid Darwiche, Lonny B. Yarmus, Alfonso Torrego, Ganesh Krishna, Pallav L. Shah, Jouke T. Annema, Felix J.F. Herth, Venerino Poletti

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Transbronchial cryobiopsies (TBCB) have recently been introduced as a promising and safer alternative to surgical lung biopsy in the diagnostic approach to diffuse parenchymal lung diseases (DPLD). Despite a substantial and expanding body of literature, the technique has not yet been standardized and its place in the diagnostic algorithm of DPLD remains to be defined. In part, this reflects concerns over the diagnostic yield and safety of the procedure, together with the rapid spread of the technique without competency and safety standards; furthermore, there is a substantial procedural variability among centers and interventional pulmonologists. We report this expert statement proposed during the third international conference on “Transbronchial Cryobiopsy in Diffuse Parenchymal Lung Disease” (Ravenna, October 27–28, 2016), which formulates evidence- and expert-based suggestions on the indications, contraindications, patient selection, and procedural aspects of the procedure. The following 5 domains were reviewed: (1) what is the role of TBCB in the diagnostic evaluation of DPLD: patient selection; (2) pathological considerations; (3) contraindications and safety considerations; (4) how should TBCB be performed and in what procedural environment; and (5) who should perform TBCB. Finally, the existence of white paper recommendations may also reassure local hospital credentialing committees tasked with endorsing an adoption of the technique.

Original languageEnglish (US)
JournalRespiration
DOIs
StateAccepted/In press - Jan 9 2018

Fingerprint

Interstitial Lung Diseases
Safety
Patient Selection
Credentialing
Biopsy
Lung

Keywords

  • Bronchoscopy
  • Diffuse parenchymal lung disease
  • Interstitial lung disease
  • Safety
  • Transbronchial lung cryobiopsy

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Transbronchial Cryobiopsies for the Diagnosis of Diffuse Parenchymal Lung Diseases : Expert Statement from the Cryobiopsy Working Group on Safety and Utility and a Call for Standardization of the Procedure. / Hetzel, Jürgen; Maldonado, Fabien; Ravaglia, Claudia; Wells, Athol U.; Colby, Thomas V.; Tomassetti, Sara; Ryu, Jay H; Fruchter, Oren; Piciucchi, Sara; Dubini, Alessandra; Cavazza, Alberto; Chilosi, Marco; Sverzellati, Nicola; Valeyre, Dominique; Leduc, Dimitri; Walsh, Simon L.F.; Gasparini, Stefano; Hetzel, Martin; Hagmeyer, Lars; Haentschel, Maik; Eberhardt, Ralf; Darwiche, Kaid; Yarmus, Lonny B.; Torrego, Alfonso; Krishna, Ganesh; Shah, Pallav L.; Annema, Jouke T.; Herth, Felix J.F.; Poletti, Venerino.

In: Respiration, 09.01.2018.

Research output: Contribution to journalArticle

Hetzel, J, Maldonado, F, Ravaglia, C, Wells, AU, Colby, TV, Tomassetti, S, Ryu, JH, Fruchter, O, Piciucchi, S, Dubini, A, Cavazza, A, Chilosi, M, Sverzellati, N, Valeyre, D, Leduc, D, Walsh, SLF, Gasparini, S, Hetzel, M, Hagmeyer, L, Haentschel, M, Eberhardt, R, Darwiche, K, Yarmus, LB, Torrego, A, Krishna, G, Shah, PL, Annema, JT, Herth, FJF & Poletti, V 2018, 'Transbronchial Cryobiopsies for the Diagnosis of Diffuse Parenchymal Lung Diseases: Expert Statement from the Cryobiopsy Working Group on Safety and Utility and a Call for Standardization of the Procedure', Respiration. https://doi.org/10.1159/000484055
Hetzel, Jürgen ; Maldonado, Fabien ; Ravaglia, Claudia ; Wells, Athol U. ; Colby, Thomas V. ; Tomassetti, Sara ; Ryu, Jay H ; Fruchter, Oren ; Piciucchi, Sara ; Dubini, Alessandra ; Cavazza, Alberto ; Chilosi, Marco ; Sverzellati, Nicola ; Valeyre, Dominique ; Leduc, Dimitri ; Walsh, Simon L.F. ; Gasparini, Stefano ; Hetzel, Martin ; Hagmeyer, Lars ; Haentschel, Maik ; Eberhardt, Ralf ; Darwiche, Kaid ; Yarmus, Lonny B. ; Torrego, Alfonso ; Krishna, Ganesh ; Shah, Pallav L. ; Annema, Jouke T. ; Herth, Felix J.F. ; Poletti, Venerino. / Transbronchial Cryobiopsies for the Diagnosis of Diffuse Parenchymal Lung Diseases : Expert Statement from the Cryobiopsy Working Group on Safety and Utility and a Call for Standardization of the Procedure. In: Respiration. 2018.
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abstract = "Transbronchial cryobiopsies (TBCB) have recently been introduced as a promising and safer alternative to surgical lung biopsy in the diagnostic approach to diffuse parenchymal lung diseases (DPLD). Despite a substantial and expanding body of literature, the technique has not yet been standardized and its place in the diagnostic algorithm of DPLD remains to be defined. In part, this reflects concerns over the diagnostic yield and safety of the procedure, together with the rapid spread of the technique without competency and safety standards; furthermore, there is a substantial procedural variability among centers and interventional pulmonologists. We report this expert statement proposed during the third international conference on “Transbronchial Cryobiopsy in Diffuse Parenchymal Lung Disease” (Ravenna, October 27–28, 2016), which formulates evidence- and expert-based suggestions on the indications, contraindications, patient selection, and procedural aspects of the procedure. The following 5 domains were reviewed: (1) what is the role of TBCB in the diagnostic evaluation of DPLD: patient selection; (2) pathological considerations; (3) contraindications and safety considerations; (4) how should TBCB be performed and in what procedural environment; and (5) who should perform TBCB. Finally, the existence of white paper recommendations may also reassure local hospital credentialing committees tasked with endorsing an adoption of the technique.",
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AU - Maldonado, Fabien

AU - Ravaglia, Claudia

AU - Wells, Athol U.

AU - Colby, Thomas V.

AU - Tomassetti, Sara

AU - Ryu, Jay H

AU - Fruchter, Oren

AU - Piciucchi, Sara

AU - Dubini, Alessandra

AU - Cavazza, Alberto

AU - Chilosi, Marco

AU - Sverzellati, Nicola

AU - Valeyre, Dominique

AU - Leduc, Dimitri

AU - Walsh, Simon L.F.

AU - Gasparini, Stefano

AU - Hetzel, Martin

AU - Hagmeyer, Lars

AU - Haentschel, Maik

AU - Eberhardt, Ralf

AU - Darwiche, Kaid

AU - Yarmus, Lonny B.

AU - Torrego, Alfonso

AU - Krishna, Ganesh

AU - Shah, Pallav L.

AU - Annema, Jouke T.

AU - Herth, Felix J.F.

AU - Poletti, Venerino

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