Transactivation of gp130 in myeloma cells

Jena D. French, Denise K. Walters, Diane F Jelinek

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Receptor transactivation, i.e., interaction between unrelated receptor systems, is a growing theme in cytokine and growth factor signaling. In this study we reveal for the first time the ability of IFN-α to transactivate gp130 in myeloma cells. An epidermal growth factor receptor/gp130 chimeric receptor previously shown by us to transactivate endogenous gp130, provided a complementary tool to study the underlying mechanisms of receptor cross-talk. Further analysis revealed that transactivation of gp130 by IFN-α did not require the extracellular or trans-membrane domain of gp130. Moreover, transactivation of gp130 was critically dependent upon Janus kinase activation by the initiating receptor and correlated with rapid and sustained Janus kinase 1 and tyrosine kinase (Tyk) 2 tyrosine phosphorylation. Finally, transactivation of gp130 may be a common theme in myeloma cells, perhaps providing a mechanism for enhanced or qualitatively distinct cellular responses to specific stimuli.

Original languageEnglish (US)
Pages (from-to)3717-3723
Number of pages7
JournalJournal of Immunology
Volume170
Issue number7
StatePublished - Apr 1 2003

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Transcriptional Activation
Janus Kinase 1
Receptor Cross-Talk
TYK2 Kinase
Janus Kinases
Epidermal Growth Factor Receptor
Intercellular Signaling Peptides and Proteins
Phosphorylation
Cytokines
Membranes

ASJC Scopus subject areas

  • Immunology

Cite this

French, J. D., Walters, D. K., & Jelinek, D. F. (2003). Transactivation of gp130 in myeloma cells. Journal of Immunology, 170(7), 3717-3723.

Transactivation of gp130 in myeloma cells. / French, Jena D.; Walters, Denise K.; Jelinek, Diane F.

In: Journal of Immunology, Vol. 170, No. 7, 01.04.2003, p. 3717-3723.

Research output: Contribution to journalArticle

French, JD, Walters, DK & Jelinek, DF 2003, 'Transactivation of gp130 in myeloma cells', Journal of Immunology, vol. 170, no. 7, pp. 3717-3723.
French JD, Walters DK, Jelinek DF. Transactivation of gp130 in myeloma cells. Journal of Immunology. 2003 Apr 1;170(7):3717-3723.
French, Jena D. ; Walters, Denise K. ; Jelinek, Diane F. / Transactivation of gp130 in myeloma cells. In: Journal of Immunology. 2003 ; Vol. 170, No. 7. pp. 3717-3723.
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