Trans fatty acid intake is associated with increased risk and n3 fatty acid intake with reduced risk of non-hodgkin Lymphoma

Bridget Charbonneau, Helen M. O'Connor, Alice H. Wang, Mark Liebow, Carrie A Thompson, Zachary S. Fredericksen, William R. Macon, Susan L Slager, Timothy G. Call, Thomas Matthew Habermann, James R Cerhan

Research output: Contribution to journalArticle

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Abstract

We evaluated the association of dietary fat and protein intake with risk of non-Hodgkin lymphoma (NHL) in a clinic-based study in 603 cases (including 218 chronic lymphocytic leukemia/small lymphocytic lymphoma, 146 follicular lymphoma, and 105 diffuse large B-cell lymphoma) and 1007 frequency-matched controls. Usual diet was assessed with a 128-item food-frequency questionnaire. Unconditional logistic regression was used to estimate ORs and 95% CIs, and polytomous logistic regression was used to assess subtype-specific risks. trans Fatty acid (TFA) intake was positively associated with NHL risk [OR = 1.60 for highest vs. lowest quartile (95% CI = 1.18, 2.15); P-trend = 0.0014], n3 (ω3) fatty acid intake was inversely associated with risk [OR = 0.48 (95% CI = 0.35, 0.65); P-trend < 0.0001], and there was no association with total, animal, plant-based, or saturated fat intake. When examining intake of specific foods, processed meat [OR = 1.37 (95% CI = 1.02, 1.83); P-trend = 0.03], milk containing any fat [OR = 1.47 (95% CI = 1.16, 1.88); P-trend = 0.0025], and high-fat ice cream [OR = 4.03 (95% CI = 2.80, 5.80); P-trend < 0.0001], intakes were positively associated with risk, whereas intakes of fresh fish and total seafood [OR = 0.61 (95% CI = 0.46, 0.80); P-trend = 0.0025] were inversely associated with risk. Overall, there was little evidence for NHL subtype-specific heterogeneity. In conclusion, diets high in TFAs, processed meats, and higher fat dairy products were positively associated with NHL risk, whereas diets high in n3 fatty acids and total seafood were inversely associated with risk.

Original languageEnglish (US)
Pages (from-to)672-681
Number of pages10
JournalJournal of Nutrition
Volume143
Issue number5
DOIs
StatePublished - May 2013

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Trans Fatty Acids
Omega-3 Fatty Acids
Non-Hodgkin's Lymphoma
Fats
Seafood
B-Cell Chronic Lymphocytic Leukemia
Diet
Meat
Logistic Models
Ice Cream
Follicular Lymphoma
Dairy Products
Lymphoma, Large B-Cell, Diffuse
Dietary Proteins
Dietary Fats
Fishes
Milk
Eating
Food

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Trans fatty acid intake is associated with increased risk and n3 fatty acid intake with reduced risk of non-hodgkin Lymphoma. / Charbonneau, Bridget; O'Connor, Helen M.; Wang, Alice H.; Liebow, Mark; Thompson, Carrie A; Fredericksen, Zachary S.; Macon, William R.; Slager, Susan L; Call, Timothy G.; Habermann, Thomas Matthew; Cerhan, James R.

In: Journal of Nutrition, Vol. 143, No. 5, 05.2013, p. 672-681.

Research output: Contribution to journalArticle

Charbonneau, Bridget ; O'Connor, Helen M. ; Wang, Alice H. ; Liebow, Mark ; Thompson, Carrie A ; Fredericksen, Zachary S. ; Macon, William R. ; Slager, Susan L ; Call, Timothy G. ; Habermann, Thomas Matthew ; Cerhan, James R. / Trans fatty acid intake is associated with increased risk and n3 fatty acid intake with reduced risk of non-hodgkin Lymphoma. In: Journal of Nutrition. 2013 ; Vol. 143, No. 5. pp. 672-681.
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abstract = "We evaluated the association of dietary fat and protein intake with risk of non-Hodgkin lymphoma (NHL) in a clinic-based study in 603 cases (including 218 chronic lymphocytic leukemia/small lymphocytic lymphoma, 146 follicular lymphoma, and 105 diffuse large B-cell lymphoma) and 1007 frequency-matched controls. Usual diet was assessed with a 128-item food-frequency questionnaire. Unconditional logistic regression was used to estimate ORs and 95{\%} CIs, and polytomous logistic regression was used to assess subtype-specific risks. trans Fatty acid (TFA) intake was positively associated with NHL risk [OR = 1.60 for highest vs. lowest quartile (95{\%} CI = 1.18, 2.15); P-trend = 0.0014], n3 (ω3) fatty acid intake was inversely associated with risk [OR = 0.48 (95{\%} CI = 0.35, 0.65); P-trend < 0.0001], and there was no association with total, animal, plant-based, or saturated fat intake. When examining intake of specific foods, processed meat [OR = 1.37 (95{\%} CI = 1.02, 1.83); P-trend = 0.03], milk containing any fat [OR = 1.47 (95{\%} CI = 1.16, 1.88); P-trend = 0.0025], and high-fat ice cream [OR = 4.03 (95{\%} CI = 2.80, 5.80); P-trend < 0.0001], intakes were positively associated with risk, whereas intakes of fresh fish and total seafood [OR = 0.61 (95{\%} CI = 0.46, 0.80); P-trend = 0.0025] were inversely associated with risk. Overall, there was little evidence for NHL subtype-specific heterogeneity. In conclusion, diets high in TFAs, processed meats, and higher fat dairy products were positively associated with NHL risk, whereas diets high in n3 fatty acids and total seafood were inversely associated with risk.",
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AU - Liebow, Mark

AU - Thompson, Carrie A

AU - Fredericksen, Zachary S.

AU - Macon, William R.

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