Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A

Hansong Wang, Terrilea Burnett, Suminori Kono, Christopher A. Haiman, Motoki Iwasaki, Lynne R. Wilkens, Lenora W.M. Loo, David Van Den Berg, Laurence N. Kolonel, Brian E. Henderson, Temitope O. Keku, Robert S. Sandler, Lisa B. Signorello, William J. Blot, Polly A. Newcomb, Mala Pande, Christopher I. Amos, Dee W. West, Stéphane Bézieau, Sonja I. BerndtBrent W. Zanke, Li Hsu, Noralane M. Lindor, Robert W. Haile, John L. Hopper, Mark A. Jenkins, Steven Gallinger, Graham Casey, Stephanie L. Stenzel, Fredrick R. Schumacher, Ulrike Peters, Stephen B. Gruber, Shoichiro Tsugane, Daniel O. Stram, Loïc Le Marchand

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

The genetic basis of sporadic colorectal cancer (CRC) is not well explained by known risk polymorphisms. Here we perform a meta-analysis of two genome-wide association studies in 2,627 cases and 3,797 controls of Japanese ancestry and 1,894 cases and 4,703 controls of African ancestry, to identify genetic variants that contribute to CRC susceptibility. We replicate genome-wide statistically significant associations (P<5 × 10-8) in 16,823 cases and 18,211 controls of European ancestry. This study reveals a new pan-ethnic CRC risk locus at 10q25 (rs12241008, intronic to VTI1A; P=1.4 × 10 -9), providing additional insight into the aetiology of CRC and highlighting the value of association mapping in diverse populations.

Original languageEnglish (US)
Article number4613
JournalNature communications
Volume5
DOIs
StatePublished - Aug 8 2014

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

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