Tranexamic Acid Benefits Total Joint Arthroplasty Patients Regardless of Preoperative Hemoglobin Value

Daniel R. Whiting, Christopher M. Duncan, Rafael J. Sierra, Hugh M. Smith

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

While tranexamic acid (TXA) reduces transfusion in total joint arthroplasty (TJA), it remains unclear whether there is a preoperative hemoglobin (Hgb) threshold above which it is no longer beneficial. 2100 primary TJA patients were retrospectively categorized by preoperative Hgb; 1161 (55%) received TXA. Transfusion rates decreased with TXA in all groups; with Hgb > 15 the transfusion rate was 0.5% with TXA and 4.5% without (P=0.0086); with Hgb > 11 the transfusion rate was 4.7% with TXA and 18.7% without (P<0.0001). Patients receiving TXA had a shorter LOS by 0.51 days (P<0.0001). Patients receiving a postoperative transfusion had a longer LOS by 0.69. days (P<0.0001). TXA should be considered in all TJA patients independent of preoperative Hgb level.

Original languageEnglish (US)
Pages (from-to)2098-2101
Number of pages4
JournalJournal of Arthroplasty
Volume30
Issue number12
DOIs
StatePublished - Dec 1 2015

Keywords

  • Hemoglobin
  • THA
  • TKA
  • Total hip arthroplasty
  • Total knee arthroplasty
  • Tranexamic acid

ASJC Scopus subject areas

  • Medicine(all)
  • Orthopedics and Sports Medicine

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