Trafficking regulation of proteins in Alzheimer's disease

Shangtong Jiang; Yanfang Li; Xian Zhang; Guojun Bu; Huaxi Xu; Yun Wu Zhang

doi:10.1186/1750-1326-9-6

Trafficking regulation of proteins in Alzheimer's disease

Shangtong Jiang, Yanfang Li, Xian Zhang, Guojun Bu, Huaxi Xu, Yun Wu Zhang

Neuroscience

Research output: Contribution to journal › Review article › peer-review

93 Scopus citations

Abstract

The β-amyloid (Aβ) peptide has been postulated to be a key determinant in the pathogenesis of Alzheimer's disease (AD). Aβ is produced through sequential cleavage of the β-amyloid precursor protein (APP) by β- and γ-secretases. APP and relevant secretases are transmembrane proteins and traffic through the secretory pathway in a highly regulated fashion. Perturbation of their intracellular trafficking may affect dynamic interactions among these proteins, thus altering Aβ generation and accelerating disease pathogenesis. Herein, we review recent progress elucidating the regulation of intracellular trafficking of these essential protein components in AD.

Original language	English (US)
Article number	6
Journal	Molecular neurodegeneration
Volume	9
Issue number	1
DOIs	https://doi.org/10.1186/1750-1326-9-6
State	Published - Jan 11 2014

Keywords

A Disintegrin and Metalloprotease 10
Alzheimer's disease
Amyloid beta (A4) precursor protein
Beta-site APP-cleaving enzyme 1
Trafficking
α-secretase
β-secretase
γ-secretase

ASJC Scopus subject areas

Molecular Biology
Clinical Neurology
Cellular and Molecular Neuroscience

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10.1186/1750-1326-9-6

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title = "Trafficking regulation of proteins in Alzheimer's disease",

abstract = "The β-amyloid (Aβ) peptide has been postulated to be a key determinant in the pathogenesis of Alzheimer's disease (AD). Aβ is produced through sequential cleavage of the β-amyloid precursor protein (APP) by β- and γ-secretases. APP and relevant secretases are transmembrane proteins and traffic through the secretory pathway in a highly regulated fashion. Perturbation of their intracellular trafficking may affect dynamic interactions among these proteins, thus altering Aβ generation and accelerating disease pathogenesis. Herein, we review recent progress elucidating the regulation of intracellular trafficking of these essential protein components in AD.",

keywords = "A Disintegrin and Metalloprotease 10, Alzheimer's disease, Amyloid beta (A4) precursor protein, Beta-site APP-cleaving enzyme 1, Trafficking, α-secretase, β-secretase, γ-secretase",

author = "Shangtong Jiang and Yanfang Li and Xian Zhang and Guojun Bu and Huaxi Xu and Zhang, {Yun Wu}",

note = "Funding Information: We thank Drs. Timothy Huang and Xin Wang for proofreading this manuscript. This work was supported by grants from the National Institutes of Health (R01AG038710, R01AG021173, R01AG044420 and R01NS046673), the Alzheimer{\textquoteright}s Association, National Natural Science Foundation of China (81225008, 81000540, 81161120496, 91332112 and 91332114), the Fundamental Research Funds for the Central Universities of China, and Fok Ying Tung Education Foundation.",

year = "2014",

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doi = "10.1186/1750-1326-9-6",

language = "English (US)",

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T1 - Trafficking regulation of proteins in Alzheimer's disease

AU - Jiang, Shangtong

AU - Li, Yanfang

AU - Zhang, Xian

AU - Bu, Guojun

AU - Xu, Huaxi

AU - Zhang, Yun Wu

N1 - Funding Information: We thank Drs. Timothy Huang and Xin Wang for proofreading this manuscript. This work was supported by grants from the National Institutes of Health (R01AG038710, R01AG021173, R01AG044420 and R01NS046673), the Alzheimer’s Association, National Natural Science Foundation of China (81225008, 81000540, 81161120496, 91332112 and 91332114), the Fundamental Research Funds for the Central Universities of China, and Fok Ying Tung Education Foundation.

PY - 2014/1/11

Y1 - 2014/1/11

N2 - The β-amyloid (Aβ) peptide has been postulated to be a key determinant in the pathogenesis of Alzheimer's disease (AD). Aβ is produced through sequential cleavage of the β-amyloid precursor protein (APP) by β- and γ-secretases. APP and relevant secretases are transmembrane proteins and traffic through the secretory pathway in a highly regulated fashion. Perturbation of their intracellular trafficking may affect dynamic interactions among these proteins, thus altering Aβ generation and accelerating disease pathogenesis. Herein, we review recent progress elucidating the regulation of intracellular trafficking of these essential protein components in AD.

AB - The β-amyloid (Aβ) peptide has been postulated to be a key determinant in the pathogenesis of Alzheimer's disease (AD). Aβ is produced through sequential cleavage of the β-amyloid precursor protein (APP) by β- and γ-secretases. APP and relevant secretases are transmembrane proteins and traffic through the secretory pathway in a highly regulated fashion. Perturbation of their intracellular trafficking may affect dynamic interactions among these proteins, thus altering Aβ generation and accelerating disease pathogenesis. Herein, we review recent progress elucidating the regulation of intracellular trafficking of these essential protein components in AD.

KW - A Disintegrin and Metalloprotease 10

KW - Alzheimer's disease

KW - Amyloid beta (A4) precursor protein

KW - Beta-site APP-cleaving enzyme 1

KW - Trafficking

KW - α-secretase

KW - β-secretase

KW - γ-secretase

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JO - Molecular neurodegeneration

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Trafficking regulation of proteins in Alzheimer's disease

Abstract

Keywords

ASJC Scopus subject areas

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