Trafficking of G protein-coupled receptors

Matthew M Drake, Sudha K. Shenoy, Robert J. Lefkowitz

Research output: Contribution to journalArticle

221 Citations (Scopus)

Abstract

G protein-coupled receptors (GPCRs) play an integral role in the signal transduction of an enormous array of biological phenomena, thereby serving to modulate at a molecular level almost all components of human biology. This role is nowhere more evident than in cardiovascular biology, where GPCRs regulate such core measures of cardiovascular function as heart rate, contractility, and vascular tone. GPCR/ligand interaction initiates signal transduction cascades, and requires the presence of the receptor at the plasma membrane. Plasma membrane localization is in turn a function of the delivery of a receptor to and removal from the cell surface, a concept defined most broadly as receptor trafficking. This review illuminates our current view of GPCR trafficking, particularly within the cardiovascular system, as well as highlights the recent and provocative finding that components of the GPCR trafficking machinery can facilitate GPCR signaling independent of G protein activation.

Original languageEnglish (US)
Pages (from-to)570-582
Number of pages13
JournalCirculation Research
Volume99
Issue number6
DOIs
StatePublished - Sep 2006
Externally publishedYes

Fingerprint

G-Protein-Coupled Receptors
Signal Transduction
Cell Membrane
Myocardial Contraction
Biological Phenomena
Cardiovascular System
GTP-Binding Proteins
Blood Vessels
Heart Rate
Ligands

Keywords

  • β-arrestin
  • 7-transmembrane receptors
  • GPCR
  • GPCR kinase (GRK)
  • Trafficking

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Trafficking of G protein-coupled receptors. / Drake, Matthew M; Shenoy, Sudha K.; Lefkowitz, Robert J.

In: Circulation Research, Vol. 99, No. 6, 09.2006, p. 570-582.

Research output: Contribution to journalArticle

Drake, Matthew M ; Shenoy, Sudha K. ; Lefkowitz, Robert J. / Trafficking of G protein-coupled receptors. In: Circulation Research. 2006 ; Vol. 99, No. 6. pp. 570-582.
@article{470a667d1cf4487b95a4a3f1b584cfa3,
title = "Trafficking of G protein-coupled receptors",
abstract = "G protein-coupled receptors (GPCRs) play an integral role in the signal transduction of an enormous array of biological phenomena, thereby serving to modulate at a molecular level almost all components of human biology. This role is nowhere more evident than in cardiovascular biology, where GPCRs regulate such core measures of cardiovascular function as heart rate, contractility, and vascular tone. GPCR/ligand interaction initiates signal transduction cascades, and requires the presence of the receptor at the plasma membrane. Plasma membrane localization is in turn a function of the delivery of a receptor to and removal from the cell surface, a concept defined most broadly as receptor trafficking. This review illuminates our current view of GPCR trafficking, particularly within the cardiovascular system, as well as highlights the recent and provocative finding that components of the GPCR trafficking machinery can facilitate GPCR signaling independent of G protein activation.",
keywords = "β-arrestin, 7-transmembrane receptors, GPCR, GPCR kinase (GRK), Trafficking",
author = "Drake, {Matthew M} and Shenoy, {Sudha K.} and Lefkowitz, {Robert J.}",
year = "2006",
month = "9",
doi = "10.1161/01.RES.0000242563.47507.ce",
language = "English (US)",
volume = "99",
pages = "570--582",
journal = "Circulation Research",
issn = "0009-7330",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Trafficking of G protein-coupled receptors

AU - Drake, Matthew M

AU - Shenoy, Sudha K.

AU - Lefkowitz, Robert J.

PY - 2006/9

Y1 - 2006/9

N2 - G protein-coupled receptors (GPCRs) play an integral role in the signal transduction of an enormous array of biological phenomena, thereby serving to modulate at a molecular level almost all components of human biology. This role is nowhere more evident than in cardiovascular biology, where GPCRs regulate such core measures of cardiovascular function as heart rate, contractility, and vascular tone. GPCR/ligand interaction initiates signal transduction cascades, and requires the presence of the receptor at the plasma membrane. Plasma membrane localization is in turn a function of the delivery of a receptor to and removal from the cell surface, a concept defined most broadly as receptor trafficking. This review illuminates our current view of GPCR trafficking, particularly within the cardiovascular system, as well as highlights the recent and provocative finding that components of the GPCR trafficking machinery can facilitate GPCR signaling independent of G protein activation.

AB - G protein-coupled receptors (GPCRs) play an integral role in the signal transduction of an enormous array of biological phenomena, thereby serving to modulate at a molecular level almost all components of human biology. This role is nowhere more evident than in cardiovascular biology, where GPCRs regulate such core measures of cardiovascular function as heart rate, contractility, and vascular tone. GPCR/ligand interaction initiates signal transduction cascades, and requires the presence of the receptor at the plasma membrane. Plasma membrane localization is in turn a function of the delivery of a receptor to and removal from the cell surface, a concept defined most broadly as receptor trafficking. This review illuminates our current view of GPCR trafficking, particularly within the cardiovascular system, as well as highlights the recent and provocative finding that components of the GPCR trafficking machinery can facilitate GPCR signaling independent of G protein activation.

KW - β-arrestin

KW - 7-transmembrane receptors

KW - GPCR

KW - GPCR kinase (GRK)

KW - Trafficking

UR - http://www.scopus.com/inward/record.url?scp=33748751670&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33748751670&partnerID=8YFLogxK

U2 - 10.1161/01.RES.0000242563.47507.ce

DO - 10.1161/01.RES.0000242563.47507.ce

M3 - Article

VL - 99

SP - 570

EP - 582

JO - Circulation Research

JF - Circulation Research

SN - 0009-7330

IS - 6

ER -