Tracheobronchial adenoid cystic carcinoma

A clinicopathologic study of 14 cases

Elizabeth Albers, Thomas Lawrie, James H. Harrell, Eunhee S. Yi

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Study objectives: To investigate the clinicopathologic features of primary tracheobronchial adenoid cystic carcinoma (ACC), and to examine kit protein (CD117) expression, and a possible correlation between the histologic grade and Ki-67 positivity. Design: Retrospective 10-year study (from 1992 to 2001). Setting: Referral center for interventional pulmonology. Patients: Fourteen patients referred to our institution for laser resection of tracheal or endobronchial tumors. Interventions: Twelve patients were treated primarily by laser resection via bronchoscopy with subsequent radiation therapy. The remaining two patients had tracheal resection with postoperative radiation and radiation therapy alone. Results: Fourteen patients (5 men and 9 women) had an average age of 44 years at diagnosis (age range, 29 to 57 years). Five of 14 patients were smokers (average smoking history, 28.5 pack-years), 8 were nonsmokers, and the smoking history was unknown in 1 patient. Major symptoms at presentation included cough (57.1%), dyspnea (71.4%), and hoarseness (14.3%). Two patients (14.3%) presented with respiratory failure. Eleven patients (78.6%) had one or more recurrences, and 4 patients (28.6%) had metastases, primarily to the lungs. The average time to either recurrence or metastasis was 4.6 years after the initial diagnosis. Five patients (35.7%), all of whom had recurrences and/or metastasis during the course of their disease, died of their disease (average time, 8.2 years). Thirteen of 13 cases stained for CD117 were positive in the tumor cell cytoplasm with membranous accentuation. Our cases included 8 grade I tumors, 4 grade II tumors, and 2 grade III tumors, which did not correlate with the degree of Ki-67 positivity. Conclusions: Tracheobronchial ACCs in our study were more common in women and nonsmokers who presented with nonspecific respiratory symptoms and followed a clinical course generally comparable to that of tumors in the salivary glands. CD117 expression was present in all cases tested, and Ki-67 stain results did not correlate with the tumor grade.

Original languageEnglish (US)
Pages (from-to)1160-1165
Number of pages6
JournalChest
Volume125
Issue number3
DOIs
StatePublished - Mar 2004
Externally publishedYes

Fingerprint

Adenoid Cystic Carcinoma
Neoplasms
Neoplasm Metastasis
Recurrence
Lasers
Radiotherapy
Smoking
History
Hoarseness
Pulmonary Medicine
Bronchoscopy
Salivary Glands
Cough
Respiratory Insufficiency
Dyspnea
Cytoplasm
Coloring Agents
Referral and Consultation
Radiation

Keywords

  • Adenoid cystic carcinoma
  • c-kit
  • CD117
  • Ki-67
  • Tracheobronchial

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Tracheobronchial adenoid cystic carcinoma : A clinicopathologic study of 14 cases. / Albers, Elizabeth; Lawrie, Thomas; Harrell, James H.; Yi, Eunhee S.

In: Chest, Vol. 125, No. 3, 03.2004, p. 1160-1165.

Research output: Contribution to journalArticle

Albers, E, Lawrie, T, Harrell, JH & Yi, ES 2004, 'Tracheobronchial adenoid cystic carcinoma: A clinicopathologic study of 14 cases', Chest, vol. 125, no. 3, pp. 1160-1165. https://doi.org/10.1378/chest.125.3.1160
Albers, Elizabeth ; Lawrie, Thomas ; Harrell, James H. ; Yi, Eunhee S. / Tracheobronchial adenoid cystic carcinoma : A clinicopathologic study of 14 cases. In: Chest. 2004 ; Vol. 125, No. 3. pp. 1160-1165.
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N2 - Study objectives: To investigate the clinicopathologic features of primary tracheobronchial adenoid cystic carcinoma (ACC), and to examine kit protein (CD117) expression, and a possible correlation between the histologic grade and Ki-67 positivity. Design: Retrospective 10-year study (from 1992 to 2001). Setting: Referral center for interventional pulmonology. Patients: Fourteen patients referred to our institution for laser resection of tracheal or endobronchial tumors. Interventions: Twelve patients were treated primarily by laser resection via bronchoscopy with subsequent radiation therapy. The remaining two patients had tracheal resection with postoperative radiation and radiation therapy alone. Results: Fourteen patients (5 men and 9 women) had an average age of 44 years at diagnosis (age range, 29 to 57 years). Five of 14 patients were smokers (average smoking history, 28.5 pack-years), 8 were nonsmokers, and the smoking history was unknown in 1 patient. Major symptoms at presentation included cough (57.1%), dyspnea (71.4%), and hoarseness (14.3%). Two patients (14.3%) presented with respiratory failure. Eleven patients (78.6%) had one or more recurrences, and 4 patients (28.6%) had metastases, primarily to the lungs. The average time to either recurrence or metastasis was 4.6 years after the initial diagnosis. Five patients (35.7%), all of whom had recurrences and/or metastasis during the course of their disease, died of their disease (average time, 8.2 years). Thirteen of 13 cases stained for CD117 were positive in the tumor cell cytoplasm with membranous accentuation. Our cases included 8 grade I tumors, 4 grade II tumors, and 2 grade III tumors, which did not correlate with the degree of Ki-67 positivity. Conclusions: Tracheobronchial ACCs in our study were more common in women and nonsmokers who presented with nonspecific respiratory symptoms and followed a clinical course generally comparable to that of tumors in the salivary glands. CD117 expression was present in all cases tested, and Ki-67 stain results did not correlate with the tumor grade.

AB - Study objectives: To investigate the clinicopathologic features of primary tracheobronchial adenoid cystic carcinoma (ACC), and to examine kit protein (CD117) expression, and a possible correlation between the histologic grade and Ki-67 positivity. Design: Retrospective 10-year study (from 1992 to 2001). Setting: Referral center for interventional pulmonology. Patients: Fourteen patients referred to our institution for laser resection of tracheal or endobronchial tumors. Interventions: Twelve patients were treated primarily by laser resection via bronchoscopy with subsequent radiation therapy. The remaining two patients had tracheal resection with postoperative radiation and radiation therapy alone. Results: Fourteen patients (5 men and 9 women) had an average age of 44 years at diagnosis (age range, 29 to 57 years). Five of 14 patients were smokers (average smoking history, 28.5 pack-years), 8 were nonsmokers, and the smoking history was unknown in 1 patient. Major symptoms at presentation included cough (57.1%), dyspnea (71.4%), and hoarseness (14.3%). Two patients (14.3%) presented with respiratory failure. Eleven patients (78.6%) had one or more recurrences, and 4 patients (28.6%) had metastases, primarily to the lungs. The average time to either recurrence or metastasis was 4.6 years after the initial diagnosis. Five patients (35.7%), all of whom had recurrences and/or metastasis during the course of their disease, died of their disease (average time, 8.2 years). Thirteen of 13 cases stained for CD117 were positive in the tumor cell cytoplasm with membranous accentuation. Our cases included 8 grade I tumors, 4 grade II tumors, and 2 grade III tumors, which did not correlate with the degree of Ki-67 positivity. Conclusions: Tracheobronchial ACCs in our study were more common in women and nonsmokers who presented with nonspecific respiratory symptoms and followed a clinical course generally comparable to that of tumors in the salivary glands. CD117 expression was present in all cases tested, and Ki-67 stain results did not correlate with the tumor grade.

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