Tracer kinetic modeling in nuclear cardiology

Timothy R DeGrado, Steven R. Bergmann, Chin K. Ng, David M. Raffel

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The introduction of tracer kinetic modeling techniques in conjunction with nuclear imaging has allowed the assessment of physiologic processes in the myocardium in a noninvasive and quantitative manner. Alongside the development of novel radiopharmaceuticals for both positron emission tomography and single photon emission computed tomography is the clarification of their pharmacology, pharmacokinetics, and modeling strategies for assessment of physiologic rates from imaging data. Image analysis and tracer kinetic modeling techniques used in nuclear cardiology must address unique considerations related to the heart. The most commonly used tracers and modeling techniques are presently discussed, with particular attention given to methods that allow absolute quantitation of physiologic processes. The applications of these techniques are obvious in research protocols and may find more use in future clinical studies.

Original languageEnglish (US)
Pages (from-to)686-700
Number of pages15
JournalJournal of Nuclear Cardiology
Volume7
Issue number6
DOIs
StatePublished - 2000
Externally publishedYes

Fingerprint

Cardiology
Process Assessment (Health Care)
Radiopharmaceuticals
Single-Photon Emission-Computed Tomography
Positron-Emission Tomography
Myocardium
Pharmacokinetics
Pharmacology
Research
Clinical Studies

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Tracer kinetic modeling in nuclear cardiology. / DeGrado, Timothy R; Bergmann, Steven R.; Ng, Chin K.; Raffel, David M.

In: Journal of Nuclear Cardiology, Vol. 7, No. 6, 2000, p. 686-700.

Research output: Contribution to journalArticle

DeGrado, Timothy R ; Bergmann, Steven R. ; Ng, Chin K. ; Raffel, David M. / Tracer kinetic modeling in nuclear cardiology. In: Journal of Nuclear Cardiology. 2000 ; Vol. 7, No. 6. pp. 686-700.
@article{7479470694484453b04fb96ed6b52bee,
title = "Tracer kinetic modeling in nuclear cardiology",
abstract = "The introduction of tracer kinetic modeling techniques in conjunction with nuclear imaging has allowed the assessment of physiologic processes in the myocardium in a noninvasive and quantitative manner. Alongside the development of novel radiopharmaceuticals for both positron emission tomography and single photon emission computed tomography is the clarification of their pharmacology, pharmacokinetics, and modeling strategies for assessment of physiologic rates from imaging data. Image analysis and tracer kinetic modeling techniques used in nuclear cardiology must address unique considerations related to the heart. The most commonly used tracers and modeling techniques are presently discussed, with particular attention given to methods that allow absolute quantitation of physiologic processes. The applications of these techniques are obvious in research protocols and may find more use in future clinical studies.",
author = "DeGrado, {Timothy R} and Bergmann, {Steven R.} and Ng, {Chin K.} and Raffel, {David M.}",
year = "2000",
doi = "10.1067/mnc.2000.111127",
language = "English (US)",
volume = "7",
pages = "686--700",
journal = "Journal of Nuclear Cardiology",
issn = "1071-3581",
publisher = "Springer New York",
number = "6",

}

TY - JOUR

T1 - Tracer kinetic modeling in nuclear cardiology

AU - DeGrado, Timothy R

AU - Bergmann, Steven R.

AU - Ng, Chin K.

AU - Raffel, David M.

PY - 2000

Y1 - 2000

N2 - The introduction of tracer kinetic modeling techniques in conjunction with nuclear imaging has allowed the assessment of physiologic processes in the myocardium in a noninvasive and quantitative manner. Alongside the development of novel radiopharmaceuticals for both positron emission tomography and single photon emission computed tomography is the clarification of their pharmacology, pharmacokinetics, and modeling strategies for assessment of physiologic rates from imaging data. Image analysis and tracer kinetic modeling techniques used in nuclear cardiology must address unique considerations related to the heart. The most commonly used tracers and modeling techniques are presently discussed, with particular attention given to methods that allow absolute quantitation of physiologic processes. The applications of these techniques are obvious in research protocols and may find more use in future clinical studies.

AB - The introduction of tracer kinetic modeling techniques in conjunction with nuclear imaging has allowed the assessment of physiologic processes in the myocardium in a noninvasive and quantitative manner. Alongside the development of novel radiopharmaceuticals for both positron emission tomography and single photon emission computed tomography is the clarification of their pharmacology, pharmacokinetics, and modeling strategies for assessment of physiologic rates from imaging data. Image analysis and tracer kinetic modeling techniques used in nuclear cardiology must address unique considerations related to the heart. The most commonly used tracers and modeling techniques are presently discussed, with particular attention given to methods that allow absolute quantitation of physiologic processes. The applications of these techniques are obvious in research protocols and may find more use in future clinical studies.

UR - http://www.scopus.com/inward/record.url?scp=0034525824&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034525824&partnerID=8YFLogxK

U2 - 10.1067/mnc.2000.111127

DO - 10.1067/mnc.2000.111127

M3 - Article

VL - 7

SP - 686

EP - 700

JO - Journal of Nuclear Cardiology

JF - Journal of Nuclear Cardiology

SN - 1071-3581

IS - 6

ER -