TY - JOUR
T1 - Toxicity to heavy metals and relationship to seizure thresholds
AU - Adler, Martin W.
AU - Adler, Charles H.
PY - 1977/11
Y1 - 1977/11
N2 - The present study was designed to provide information on the effects of lead, mercury, and nickel on lethality, body weight, and brain excitability in the adult rat. Both short- (2 days) and long-term (6 wk) drug administrations were carried out in adult male albino rats (Sprague-Dawley, Zivic-Miller). Based on the mglkg/day of drug given over a 2-day period, the LD50 values were as follows: Pb(Ac)2, 215; Pb(NO3)2, 65.9; MMC, 11.9; HgCl2, 4.5; Ni(Ac)2, 35-40; NiS04, 35-40. High doses of each of the metals administered acutely caused a drop in body weight but had an inconsistent effect on flurothyl-induced seizure thresholds. Pb(Ac)2, 200 mglkg/day for 2 days, produced a statistically significant anticonvulsant effect, while 50 mglkg Pb(N03)2 resulted in a fall in threshold. Both NiS04 and Ni(Ac)2, 30 mg/kg, increased seizure threshold. Neither the organic nor inorganic mercury altered thresholds. Long-term administration of Pb(Ac)2, MMC, or HgCl2, resulted in marked effects on body weight but no significant change in brain excitability.
AB - The present study was designed to provide information on the effects of lead, mercury, and nickel on lethality, body weight, and brain excitability in the adult rat. Both short- (2 days) and long-term (6 wk) drug administrations were carried out in adult male albino rats (Sprague-Dawley, Zivic-Miller). Based on the mglkg/day of drug given over a 2-day period, the LD50 values were as follows: Pb(Ac)2, 215; Pb(NO3)2, 65.9; MMC, 11.9; HgCl2, 4.5; Ni(Ac)2, 35-40; NiS04, 35-40. High doses of each of the metals administered acutely caused a drop in body weight but had an inconsistent effect on flurothyl-induced seizure thresholds. Pb(Ac)2, 200 mglkg/day for 2 days, produced a statistically significant anticonvulsant effect, while 50 mglkg Pb(N03)2 resulted in a fall in threshold. Both NiS04 and Ni(Ac)2, 30 mg/kg, increased seizure threshold. Neither the organic nor inorganic mercury altered thresholds. Long-term administration of Pb(Ac)2, MMC, or HgCl2, resulted in marked effects on body weight but no significant change in brain excitability.
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U2 - 10.1002/cpt1977225part2774
DO - 10.1002/cpt1977225part2774
M3 - Article
C2 - 913036
AN - SCOPUS:0017759849
SN - 0009-9236
VL - 22
SP - 774
EP - 779
JO - Clinical pharmacology and therapeutics
JF - Clinical pharmacology and therapeutics
IS - 5 PART 2
ER -