Abstract
AL amyloidosis is a plasma cell disorder in which tissue deposition of immunoglobulin light chains leads to organ dysfunction. Recent reports of high-dose therapy with autologous stem cell transplantation for amyloidosis suggest higher response rates and extended survival compared to those seen with conventional chemotherapy. However, substantial treatment-related toxicity has been observed. This case series describes our institutional experience with autologous transplantation in four patients with amyloidosis with an emphasis on unique gastrointestinal toxicities, including toxic megacolon.
Original language | English (US) |
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Pages (from-to) | 279-285 |
Number of pages | 7 |
Journal | Bone Marrow Transplantation |
Volume | 30 |
Issue number | 5 |
DOIs | |
State | Published - Sep 2002 |
Keywords
- AL amyloidosis
- High-dose chemotherapy
- Stem cell transplantation
- Toxic megacolon
ASJC Scopus subject areas
- Hematology
- Transplantation