Toxic megacolon: A life-threatening complication of high-dose therapy and autologous stem cell transplantation among patients with AL amyloidosis

B. M. Hayes-Lattin, P. T. Curtin, W. H. Fleming, J. F. Leis, D. E. Stepan, S. Schubach, R. T. Maziarz

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

AL amyloidosis is a plasma cell disorder in which tissue deposition of immunoglobulin light chains leads to organ dysfunction. Recent reports of high-dose therapy with autologous stem cell transplantation for amyloidosis suggest higher response rates and extended survival compared to those seen with conventional chemotherapy. However, substantial treatment-related toxicity has been observed. This case series describes our institutional experience with autologous transplantation in four patients with amyloidosis with an emphasis on unique gastrointestinal toxicities, including toxic megacolon.

Original languageEnglish (US)
Pages (from-to)279-285
Number of pages7
JournalBone Marrow Transplantation
Volume30
Issue number5
DOIs
StatePublished - Sep 1 2002

Keywords

  • AL amyloidosis
  • High-dose chemotherapy
  • Stem cell transplantation
  • Toxic megacolon

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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