The essay, dedicated to Academician Drago Ikić-a pioneer in the development and preparation of vaccines for prevention of infectious diseases at the occasion of his 95th birthday, discusses the relative failure of therapeutic vaccination for malignant diseases. From a personal perspective, the author recounts the historic examples of »spontaneous« tumor regressions in conjunction with acute infections; development of the first marketed purportedly antigen-specific cellular immunotherapy (for metastatic prostate cancer); the paradox of immunotherapy effect on overall survival, but not on time to disease progression; and the promise of the new complex systems-based approaches to a more rational design of cellular immunotherapy in the hope of bringing this mode of treatment into the therapeutic mainstream and standard of care.
|Original language||English (US)|
|Number of pages||13|
|State||Published - Dec 1 2012|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Agricultural and Biological Sciences(all)