Toward understanding the genetics of regulatory t cells in ovarian cancer

Melissa S. DeRycke, Bridget Charbonneau, Claudia C. Preston, Kimberly R. Kalli, Keith L Knutson, David N. Rider, Ellen L Goode

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Tumor-infiltrating regulatory T cells (Tregs) promote immune evasion and are associated with poor disease outcome in patients affected by various malignancies. We have recently demonstrated that several, inherited single nucleotide polymorphisms affecting Treg-related genes influence the survival of ovarian cancer patients, providing novel insights into possible mechanisms of immune escape.

Original languageEnglish (US)
Article numbere24572
JournalOncoImmunology
Volume2
Issue number6
DOIs
StatePublished - Jun 2013

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Keywords

  • CD134
  • CD80
  • GARP
  • GITR
  • Inherited variants
  • LRRC32
  • Ovarian cancer
  • OX40
  • Regulatory t cells
  • Rgs1
  • Tnfrsf18
  • Tnfrsf4

ASJC Scopus subject areas

  • Immunology and Allergy
  • Oncology
  • Immunology

Cite this

DeRycke, M. S., Charbonneau, B., Preston, C. C., Kalli, K. R., Knutson, K. L., Rider, D. N., & Goode, E. L. (2013). Toward understanding the genetics of regulatory t cells in ovarian cancer. OncoImmunology, 2(6), [e24572]. https://doi.org/10.4161/onci.24572