Toward understanding the genetics of regulatory t cells in ovarian cancer

Melissa S. DeRycke, Bridget Charbonneau, Claudia C. Preston, Kimberly R. Kalli, Keith L. Knutson, David N. Rider, Ellen L. Goode

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Tumor-infiltrating regulatory T cells (Tregs) promote immune evasion and are associated with poor disease outcome in patients affected by various malignancies. We have recently demonstrated that several, inherited single nucleotide polymorphisms affecting Treg-related genes influence the survival of ovarian cancer patients, providing novel insights into possible mechanisms of immune escape.

Original languageEnglish (US)
Article numbere24572
JournalOncoImmunology
Volume2
Issue number6
DOIs
StatePublished - Jun 2013

Keywords

  • CD134
  • CD80
  • GARP
  • GITR
  • Inherited variants
  • LRRC32
  • OX40
  • Ovarian cancer
  • Regulatory t cells
  • Rgs1
  • Tnfrsf18
  • Tnfrsf4

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology

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