Toward understanding the genetics of regulatory t cells in ovarian cancer

Melissa S. DeRycke; Bridget Charbonneau; Claudia C. Preston; Kimberly R. Kalli; Keith L. Knutson; David N. Rider; Ellen L. Goode

doi:10.4161/onci.24572

Toward understanding the genetics of regulatory t cells in ovarian cancer

Melissa S. DeRycke, Bridget Charbonneau, Claudia C. Preston, Kimberly R. Kalli, Keith L. Knutson, David N. Rider, Ellen L. Goode

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Tumor-infiltrating regulatory T cells (Tregs) promote immune evasion and are associated with poor disease outcome in patients affected by various malignancies. We have recently demonstrated that several, inherited single nucleotide polymorphisms affecting Treg-related genes influence the survival of ovarian cancer patients, providing novel insights into possible mechanisms of immune escape.

Original language	English (US)
Article number	e24572
Journal	OncoImmunology
Volume	2
Issue number	6
DOIs	https://doi.org/10.4161/onci.24572
State	Published - Jun 2013

Keywords

CD134
CD80
GARP
GITR
Inherited variants
LRRC32
OX40
Ovarian cancer
Regulatory t cells
Rgs1
Tnfrsf18
Tnfrsf4

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Oncology

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title = "Toward understanding the genetics of regulatory t cells in ovarian cancer",

abstract = "Tumor-infiltrating regulatory T cells (Tregs) promote immune evasion and are associated with poor disease outcome in patients affected by various malignancies. We have recently demonstrated that several, inherited single nucleotide polymorphisms affecting Treg-related genes influence the survival of ovarian cancer patients, providing novel insights into possible mechanisms of immune escape.",

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author = "DeRycke, {Melissa S.} and Bridget Charbonneau and Preston, {Claudia C.} and Kalli, {Kimberly R.} and Knutson, {Keith L.} and Rider, {David N.} and Goode, {Ellen L.}",

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AU - DeRycke, Melissa S.

AU - Charbonneau, Bridget

AU - Preston, Claudia C.

AU - Kalli, Kimberly R.

AU - Knutson, Keith L.

AU - Rider, David N.

AU - Goode, Ellen L.

PY - 2013/6

Y1 - 2013/6

N2 - Tumor-infiltrating regulatory T cells (Tregs) promote immune evasion and are associated with poor disease outcome in patients affected by various malignancies. We have recently demonstrated that several, inherited single nucleotide polymorphisms affecting Treg-related genes influence the survival of ovarian cancer patients, providing novel insights into possible mechanisms of immune escape.

AB - Tumor-infiltrating regulatory T cells (Tregs) promote immune evasion and are associated with poor disease outcome in patients affected by various malignancies. We have recently demonstrated that several, inherited single nucleotide polymorphisms affecting Treg-related genes influence the survival of ovarian cancer patients, providing novel insights into possible mechanisms of immune escape.

KW - CD134

KW - CD80

KW - GARP

KW - GITR

KW - Inherited variants

KW - LRRC32

KW - OX40

KW - Ovarian cancer

KW - Regulatory t cells

KW - Rgs1

KW - Tnfrsf18

KW - Tnfrsf4

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JO - OncoImmunology

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ER -

Toward understanding the genetics of regulatory t cells in ovarian cancer

Abstract

Keywords

ASJC Scopus subject areas

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