Toward sophisticated basal ganglia neuromodulation: Review on basal ganglia deep brain stimulation

Claudio Da Cunha, Suelen L. Boschen, Alexander Gómez-A, Erika K. Ross, William S J Gibson, Hoon Ki Min, Kendall H Lee, Charles D. Blaha

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

This review presents state-of-the-art knowledge about the roles of the basal ganglia (BG) in action-selection, cognition, and motivation, and how this knowledge has been used to improve deep brain stimulation (DBS) treatment of neurological and psychiatric disorders. Such pathological conditions include Parkinson's disease, Huntington's disease, Tourette syndrome, depression, and obsessive-compulsive disorder. The first section presents evidence supporting current hypotheses of how the cortico-BG circuitry works to select motor and emotional actions, and how defects in this circuitry can cause symptoms of the BG diseases. Emphasis is given to the role of striatal dopamine on motor performance, motivated behaviors and learning of procedural memories. Next, the use of cutting-edge electrochemical techniques in animal and human studies of BG functioning under normal and disease conditions is discussed. Finally, functional neuroimaging studies are reviewed; these works have shown the relationship between cortico-BG structures activated during DBS and improvement of disease symptoms.

Original languageEnglish (US)
Pages (from-to)186-210
Number of pages25
JournalNeuroscience and Biobehavioral Reviews
Volume58
DOIs
StatePublished - Nov 1 2015

Fingerprint

Deep Brain Stimulation
Basal Ganglia
Electrochemical Techniques
Basal Ganglia Diseases
Corpus Striatum
Tourette Syndrome
Functional Neuroimaging
Obsessive-Compulsive Disorder
Huntington Disease
Nervous System Diseases
Cognition
Parkinson Disease
Psychiatry
Motivation
Dopamine
Learning
Depression
Therapeutics

Keywords

  • Deep brain stimulation
  • Electrochemistry
  • Functional magnetic resonance imaging
  • Globus pallidus
  • Human
  • Pig
  • Striatum
  • Substantia nigra
  • Subthalamic nucleus
  • Voltammetry

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Neuropsychology and Physiological Psychology

Cite this

Da Cunha, C., Boschen, S. L., Gómez-A, A., Ross, E. K., Gibson, W. S. J., Min, H. K., ... Blaha, C. D. (2015). Toward sophisticated basal ganglia neuromodulation: Review on basal ganglia deep brain stimulation. Neuroscience and Biobehavioral Reviews, 58, 186-210. https://doi.org/10.1016/j.neubiorev.2015.02.003

Toward sophisticated basal ganglia neuromodulation : Review on basal ganglia deep brain stimulation. / Da Cunha, Claudio; Boschen, Suelen L.; Gómez-A, Alexander; Ross, Erika K.; Gibson, William S J; Min, Hoon Ki; Lee, Kendall H; Blaha, Charles D.

In: Neuroscience and Biobehavioral Reviews, Vol. 58, 01.11.2015, p. 186-210.

Research output: Contribution to journalArticle

Da Cunha, Claudio ; Boschen, Suelen L. ; Gómez-A, Alexander ; Ross, Erika K. ; Gibson, William S J ; Min, Hoon Ki ; Lee, Kendall H ; Blaha, Charles D. / Toward sophisticated basal ganglia neuromodulation : Review on basal ganglia deep brain stimulation. In: Neuroscience and Biobehavioral Reviews. 2015 ; Vol. 58. pp. 186-210.
@article{14a3a5f504384cb6af408b1413138179,
title = "Toward sophisticated basal ganglia neuromodulation: Review on basal ganglia deep brain stimulation",
abstract = "This review presents state-of-the-art knowledge about the roles of the basal ganglia (BG) in action-selection, cognition, and motivation, and how this knowledge has been used to improve deep brain stimulation (DBS) treatment of neurological and psychiatric disorders. Such pathological conditions include Parkinson's disease, Huntington's disease, Tourette syndrome, depression, and obsessive-compulsive disorder. The first section presents evidence supporting current hypotheses of how the cortico-BG circuitry works to select motor and emotional actions, and how defects in this circuitry can cause symptoms of the BG diseases. Emphasis is given to the role of striatal dopamine on motor performance, motivated behaviors and learning of procedural memories. Next, the use of cutting-edge electrochemical techniques in animal and human studies of BG functioning under normal and disease conditions is discussed. Finally, functional neuroimaging studies are reviewed; these works have shown the relationship between cortico-BG structures activated during DBS and improvement of disease symptoms.",
keywords = "Deep brain stimulation, Electrochemistry, Functional magnetic resonance imaging, Globus pallidus, Human, Pig, Striatum, Substantia nigra, Subthalamic nucleus, Voltammetry",
author = "{Da Cunha}, Claudio and Boschen, {Suelen L.} and Alexander G{\'o}mez-A and Ross, {Erika K.} and Gibson, {William S J} and Min, {Hoon Ki} and Lee, {Kendall H} and Blaha, {Charles D.}",
year = "2015",
month = "11",
day = "1",
doi = "10.1016/j.neubiorev.2015.02.003",
language = "English (US)",
volume = "58",
pages = "186--210",
journal = "Neuroscience and Biobehavioral Reviews",
issn = "0149-7634",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Toward sophisticated basal ganglia neuromodulation

T2 - Review on basal ganglia deep brain stimulation

AU - Da Cunha, Claudio

AU - Boschen, Suelen L.

AU - Gómez-A, Alexander

AU - Ross, Erika K.

AU - Gibson, William S J

AU - Min, Hoon Ki

AU - Lee, Kendall H

AU - Blaha, Charles D.

PY - 2015/11/1

Y1 - 2015/11/1

N2 - This review presents state-of-the-art knowledge about the roles of the basal ganglia (BG) in action-selection, cognition, and motivation, and how this knowledge has been used to improve deep brain stimulation (DBS) treatment of neurological and psychiatric disorders. Such pathological conditions include Parkinson's disease, Huntington's disease, Tourette syndrome, depression, and obsessive-compulsive disorder. The first section presents evidence supporting current hypotheses of how the cortico-BG circuitry works to select motor and emotional actions, and how defects in this circuitry can cause symptoms of the BG diseases. Emphasis is given to the role of striatal dopamine on motor performance, motivated behaviors and learning of procedural memories. Next, the use of cutting-edge electrochemical techniques in animal and human studies of BG functioning under normal and disease conditions is discussed. Finally, functional neuroimaging studies are reviewed; these works have shown the relationship between cortico-BG structures activated during DBS and improvement of disease symptoms.

AB - This review presents state-of-the-art knowledge about the roles of the basal ganglia (BG) in action-selection, cognition, and motivation, and how this knowledge has been used to improve deep brain stimulation (DBS) treatment of neurological and psychiatric disorders. Such pathological conditions include Parkinson's disease, Huntington's disease, Tourette syndrome, depression, and obsessive-compulsive disorder. The first section presents evidence supporting current hypotheses of how the cortico-BG circuitry works to select motor and emotional actions, and how defects in this circuitry can cause symptoms of the BG diseases. Emphasis is given to the role of striatal dopamine on motor performance, motivated behaviors and learning of procedural memories. Next, the use of cutting-edge electrochemical techniques in animal and human studies of BG functioning under normal and disease conditions is discussed. Finally, functional neuroimaging studies are reviewed; these works have shown the relationship between cortico-BG structures activated during DBS and improvement of disease symptoms.

KW - Deep brain stimulation

KW - Electrochemistry

KW - Functional magnetic resonance imaging

KW - Globus pallidus

KW - Human

KW - Pig

KW - Striatum

KW - Substantia nigra

KW - Subthalamic nucleus

KW - Voltammetry

UR - http://www.scopus.com/inward/record.url?scp=84930524485&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84930524485&partnerID=8YFLogxK

U2 - 10.1016/j.neubiorev.2015.02.003

DO - 10.1016/j.neubiorev.2015.02.003

M3 - Article

C2 - 25684727

AN - SCOPUS:84930524485

VL - 58

SP - 186

EP - 210

JO - Neuroscience and Biobehavioral Reviews

JF - Neuroscience and Biobehavioral Reviews

SN - 0149-7634

ER -