TY - JOUR
T1 - Toward personalized cell therapies
T2 - Autologous menstrual blood cells for stroke
AU - Rodrigues, Maria Carolina O.
AU - Glover, Loren E.
AU - Weinbren, Nathan
AU - Rizzi, Jessica A.
AU - Ishikawa, Hiroto
AU - Shinozuka, Kazutaka
AU - Tajiri, Naoki
AU - Kaneko, Yuji
AU - Sanberg, Paul R.
AU - Allickson, Julie G.
AU - Kuzmin-Nichols, Nicole
AU - Garbuzova-Davis, Svitlana
AU - Voltarelli, Julio Cesar
AU - Cruz, Eduardo
AU - Borlongan, Cesar V.
PY - 2011
Y1 - 2011
N2 - Cell therapy has been established as an important field of research with considerable progress in the last years. At the same time, the progressive aging of the population has highlighted the importance of discovering therapeutic alternatives for diseases of high incidence and disability, such as stroke. Menstrual blood is a recently discovered source of stem cells with potential relevance for the treatment of stroke. Migration to the infarct site, modulation of the inflammatory reaction, secretion of neurotrophic factors, and possible differentiation warrant these cells as therapeutic tools. We here propose the use of autologous menstrual blood cells in the restorative treatment of the subacute phase of stroke. We highlight the availability, proliferative capacity, pluripotency, and angiogenic features of these cells and explore their mechanistic pathways of repair. Practical aspects of clinical application of menstrual blood cells for stroke will be discussed, from cell harvesting and cryopreservation to administration to the patient.
AB - Cell therapy has been established as an important field of research with considerable progress in the last years. At the same time, the progressive aging of the population has highlighted the importance of discovering therapeutic alternatives for diseases of high incidence and disability, such as stroke. Menstrual blood is a recently discovered source of stem cells with potential relevance for the treatment of stroke. Migration to the infarct site, modulation of the inflammatory reaction, secretion of neurotrophic factors, and possible differentiation warrant these cells as therapeutic tools. We here propose the use of autologous menstrual blood cells in the restorative treatment of the subacute phase of stroke. We highlight the availability, proliferative capacity, pluripotency, and angiogenic features of these cells and explore their mechanistic pathways of repair. Practical aspects of clinical application of menstrual blood cells for stroke will be discussed, from cell harvesting and cryopreservation to administration to the patient.
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U2 - 10.1155/2011/194720
DO - 10.1155/2011/194720
M3 - Review article
C2 - 22162629
AN - SCOPUS:84855521321
SN - 1110-7243
VL - 2011
JO - Journal of Biomedicine and Biotechnology
JF - Journal of Biomedicine and Biotechnology
M1 - 194720
ER -