Toward patient-specific, biologically optimized radiation therapy plans for the treatment of glioblastoma

David Corwin, Clay Holdsworth, Russell C. Rockne, Andrew D. Trister, Maciej M. Mrugala, Jason K. Rockhill, Robert D. Stewart, Mark Phillips, Kristin R. Swanson

Research output: Contribution to journalArticle

64 Scopus citations

Abstract

Purpose: To demonstrate a method of generating patient-specific, biologically-guided radiotherapy dose plans and compare them to the standard-of-care protocol. Methods and Materials: We integrated a patient-specific biomathematical model of glioma proliferation, invasion and radiotherapy with a multiobjective evolutionary algorithm for intensity-modulated radiation therapy optimization to construct individualized, biologically-guided plans for 11 glioblastoma patients. Patient-individualized, sphericallysymmetric simulations of the standard-of-care and optimized plans were compared in terms of several biological metrics. Results: The integrated model generated spatially non-uniform doses that, when compared to the standard-of-care protocol, resulted in a 67% to 93% decrease in equivalent uniform dose to normal tissue, while the therapeutic ratio, the ratio of tumor equivalent uniform dose to that of normal tissue, increased between 50% to 265%. Applying a novel metric of treatment response (Days Gained) to the patient-individualized simulation results predicted that the optimized plans would have a significant impact on delaying tumor progression, with increases from 21% to 105% for 9 of 11 patients. Conclusions: Patient-individualized simulations using the combination of a biomathematical model with an optimization algorithm for radiation therapy generated biologically-guided doses that decreased normal tissue EUD and increased therapeutic ratio with the potential to improve survival outcomes for treatment of glioblastoma.

Original languageEnglish (US)
Article numbere79115
JournalPloS one
Volume8
Issue number11
DOIs
StatePublished - Nov 12 2013

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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    Corwin, D., Holdsworth, C., Rockne, R. C., Trister, A. D., Mrugala, M. M., Rockhill, J. K., Stewart, R. D., Phillips, M., & Swanson, K. R. (2013). Toward patient-specific, biologically optimized radiation therapy plans for the treatment of glioblastoma. PloS one, 8(11), [e79115]. https://doi.org/10.1371/journal.pone.0079115