TY - JOUR
T1 - Toward office-based measurement of gastric emptying in symptomatic diabetes diabetics using [13C]octanoic acid breath test
AU - Lee, Joon Seong
AU - Camilleri, Michael
AU - Zinsmeister, Alan R.
AU - Burton, Duane D.
AU - Choi, Myung Gyu
AU - Nair, K. Sreekumaran
AU - Verlinden, Marleen
N1 - Funding Information:
This study was supported in part by a grant from Abbott Laboratories, Abbott Park, IL and in part by General Clinical Research Center grant (RR#00585) and RO1-DK54681-01 (Dr. M. Camilleri) from National Institutes of Health. The authors thank colleagues in the Diabetes Clinic at Mayo Clinic Rochester for referring patients for the study, Mr. G.C. Ford for skillful technical assistance, and Mrs. Cindy Stanislav for excellent secretarial assistance. Dr. Verlinden is employed by Abbott Laboratories.
PY - 2000
Y1 - 2000
N2 - OBJECTIVE: Current methods for measuring gastric emptying by breath test require sampling over several hours and are too inaccurate for clinical use. The aim of this study was to develop an office-based method for measuring gastric emptying of solids in patients with diabetes using a [13C]octanoic acid breath test. METHODS: In 22 symptomatic diabetic patients (17 insulin-dependent diabetes, 5 non-insulin-dependent diabetes) and 6 controls, we simultaneously measured gastric emptying of an egg meal (420 kcal) by scintigraphy and [13C]octanoic acid breath test. Conventional (nonlinear) methods for scintigraphic and [13C]octanoic acid breath test emptying and generalized linear regression method to predict scintigraphic half-life (t(1/2)) using four breath samples obtained during the first 3 h. RESULTS: Despite 8 h of breath sampling, the t(1/2) estimate using the conventional method was markedly different from the scintigraphic value (Δt(1/2): median, 113 min; range, 19-282 min). The generalized linear model (using samples at baseline, 30, and 120 or 150 min) yielded predicted scintigraphic t(LAG) and t(1/2) that were more accurate than the conventional method; mean standard deviations of differences were 16 and 27 min, respectively. Breath test correctly assessed normal or prolonged emptying in 21 of 22 patients. CONCLUSIONS: The [13C]octanoic acid breath test can be simplified to measure gastric t(LAG) and t(1/2) and can be expected to correctly identify normal t(1/2) in symptomatic diabetics. Further refinement of the model will need to include studies of patients with markedly delayed t(1/2). (C) 2000 by Am. Coll. of Gastroenterology.
AB - OBJECTIVE: Current methods for measuring gastric emptying by breath test require sampling over several hours and are too inaccurate for clinical use. The aim of this study was to develop an office-based method for measuring gastric emptying of solids in patients with diabetes using a [13C]octanoic acid breath test. METHODS: In 22 symptomatic diabetic patients (17 insulin-dependent diabetes, 5 non-insulin-dependent diabetes) and 6 controls, we simultaneously measured gastric emptying of an egg meal (420 kcal) by scintigraphy and [13C]octanoic acid breath test. Conventional (nonlinear) methods for scintigraphic and [13C]octanoic acid breath test emptying and generalized linear regression method to predict scintigraphic half-life (t(1/2)) using four breath samples obtained during the first 3 h. RESULTS: Despite 8 h of breath sampling, the t(1/2) estimate using the conventional method was markedly different from the scintigraphic value (Δt(1/2): median, 113 min; range, 19-282 min). The generalized linear model (using samples at baseline, 30, and 120 or 150 min) yielded predicted scintigraphic t(LAG) and t(1/2) that were more accurate than the conventional method; mean standard deviations of differences were 16 and 27 min, respectively. Breath test correctly assessed normal or prolonged emptying in 21 of 22 patients. CONCLUSIONS: The [13C]octanoic acid breath test can be simplified to measure gastric t(LAG) and t(1/2) and can be expected to correctly identify normal t(1/2) in symptomatic diabetics. Further refinement of the model will need to include studies of patients with markedly delayed t(1/2). (C) 2000 by Am. Coll. of Gastroenterology.
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U2 - 10.1016/S0002-9270(00)01976-6
DO - 10.1016/S0002-9270(00)01976-6
M3 - Article
C2 - 11051344
AN - SCOPUS:0033791788
SN - 0002-9270
VL - 95
SP - 2751
EP - 2761
JO - American Journal of Gastroenterology
JF - American Journal of Gastroenterology
IS - 10
ER -