Toward modeling of radio-frequency ablation lesions for image-guided left atrial fibrillation therapy: Model formulation and preliminary evaluation

Cristian A. Linte, Jon J. Camp, David R. Holmes, Maryam E. Rettmann, Douglas L. Packer, Richard A. Robb

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

In the context of image-guided left atrial fibrillation therapy, relatively very little work has been done to consider the changes that occur in the tissue during ablation in order to monitor therapy delivery. Here we describe a technique to predict the lesion progression and monitor the radio-frequency energy delivery via a thermal ablation model that uses heat transfer principles to estimate the tissue temperature distribution and resulting lesion. A preliminary evaluation of the model was conducted in ex vivo skeletal beef muscle tissue while emulating a clinically relevant tissue ablation protocol. The predicted temperature distribution within the tissue was assessed against that measured directly using fiberoptic temperature probes and showed agreement within 5°C between the model-predicted and experimentally measured tissue temperatures at prescribed locations. We believe this technique is capable of providing reasonably accurate representations of the tissue response to radio-frequency energy delivery.

Original languageEnglish (US)
Pages (from-to)261-267
Number of pages7
JournalStudies in health technology and informatics
Volume184
DOIs
StatePublished - 2013

Keywords

  • Atrial fibrillation therapy
  • Image-based radio-frequency ablation modeling
  • Image-guided catheter navigation
  • Temperature distribution and lesion characterization

ASJC Scopus subject areas

  • Biomedical Engineering
  • Health Informatics
  • Health Information Management

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