Toward improved accuracy in shear wave elastography of arteries through controlling the arterial response to ultrasound perturbation in-silico and in phantoms

Nicholas R. Hugenberg, Tuhin Roy, Hadiya Harrigan, Margherita Capriotti, Hyoung Ki Lee, Murthy Guddati, James F. Greenleaf, Matthew W Urban, Wilkins Aquino

Research output: Contribution to journalArticlepeer-review

Abstract

Dispersion-based inversion has been proposed as a viable direction for materials characterization of arteries, allowing clinicians to better study cardiovascular conditions using shear wave elastography. However, these methods rely on a priori knowledge of the vibrational modes dominating the propagating waves induced by acoustic radiation force excitation: differences between anticipated and real modal content are known to yield errors in the inversion. We seek to improve the accuracy of this process by modeling the artery as a fluid-immersed cylindrical waveguide and building an analytical framework to prescribe radiation force excitations that will selectively excite certain waveguide modes using ultrasound acoustic radiation force. We show that all even-numbered waveguide modes can be eliminated from the arterial response to perturbation, and confirm the efficacy of this approach with in silico tests that show that odd modes are preferentially excited. Finally, by analyzing data from phantom tests, we find a set of ultrasound focal parameters that demonstrate the viability of inducing the desired odd-mode response in experiments.

Original languageEnglish (US)
Article number235008
JournalPhysics in medicine and biology
Volume66
Issue number23
DOIs
StatePublished - Dec 7 2021

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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