Toward earlier diagnosis of amyotrophic lateral sclerosis: Revised criteria

Mark A Ross, R. G. Miller, L. Berchert, G. Parry, R. J. Barohn, C. Armon, W. W. Bryan, J. Petajan, S. Stromatt, J. Goodpasture, D. McGuire

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Abstract

We modified the World Federation of Neurology (WFN) diagnostic criteria for ALS to facilitate early diagnosis and used these criteria for enrollment of ALS patients in a clinical trial. The criteria developed required lower motor neuron (LMN) involvement in at least two limbs and upper motor neuron involvement in at least one region (bulbar, cervical, or lumbosacral). The EMG finding of fibrillation potentials was required for evidence of LMN involvement. Electrodiagnostic studies, neuroimaging, and laboratory studies were also used to exclude disorders that might mimic ALS. Using these criteria, the diagnosis of ALS was made at a mean time of 9.7 months from onset of symptoms, which compares favorably with the 12-month period cited in the literature. Using clinical assessment at completion of the trial, the diagnosis of ALS was believed to be accurate in those patients entered in the trial. However, pathologic confirmation of the diagnosis of ALS was not obtained. Based on our preliminary experience, we propose that these ALS diagnostic criteria will facilitate early diagnosis of ALS. Future studies should prospectively compare these criteria with the WFN criteria currently in use.

Original languageEnglish (US)
Pages (from-to)768-772
Number of pages5
JournalNeurology
Volume50
Issue number3
StatePublished - Mar 1998
Externally publishedYes

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Amyotrophic Lateral Sclerosis
Motor Neurons
Early Diagnosis
Neurology
Neuroimaging
Upper Extremity
Clinical Trials

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Ross, M. A., Miller, R. G., Berchert, L., Parry, G., Barohn, R. J., Armon, C., ... McGuire, D. (1998). Toward earlier diagnosis of amyotrophic lateral sclerosis: Revised criteria. Neurology, 50(3), 768-772.

Toward earlier diagnosis of amyotrophic lateral sclerosis : Revised criteria. / Ross, Mark A; Miller, R. G.; Berchert, L.; Parry, G.; Barohn, R. J.; Armon, C.; Bryan, W. W.; Petajan, J.; Stromatt, S.; Goodpasture, J.; McGuire, D.

In: Neurology, Vol. 50, No. 3, 03.1998, p. 768-772.

Research output: Contribution to journalArticle

Ross, MA, Miller, RG, Berchert, L, Parry, G, Barohn, RJ, Armon, C, Bryan, WW, Petajan, J, Stromatt, S, Goodpasture, J & McGuire, D 1998, 'Toward earlier diagnosis of amyotrophic lateral sclerosis: Revised criteria', Neurology, vol. 50, no. 3, pp. 768-772.
Ross MA, Miller RG, Berchert L, Parry G, Barohn RJ, Armon C et al. Toward earlier diagnosis of amyotrophic lateral sclerosis: Revised criteria. Neurology. 1998 Mar;50(3):768-772.
Ross, Mark A ; Miller, R. G. ; Berchert, L. ; Parry, G. ; Barohn, R. J. ; Armon, C. ; Bryan, W. W. ; Petajan, J. ; Stromatt, S. ; Goodpasture, J. ; McGuire, D. / Toward earlier diagnosis of amyotrophic lateral sclerosis : Revised criteria. In: Neurology. 1998 ; Vol. 50, No. 3. pp. 768-772.
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