Total IgE levels do not change 1 year after endoscopic sinus surgery in patients with chronic rhinosinusitis

Devyani Lal, Fuad M. Baroody, Eric K. Weitzel, Marcy DeTineo, Robert M. Naclerio

Research output: Contribution to journalArticle

12 Scopus citations


Background: Total IgE levels positively correlate with the amount of mucosal thickening on sinus CT scans. Our objective was to investigate whether the levels of total serum IgE decreased 1 year after endoscopic sinus surgery in patients with chronic rhinosinusitis, suggesting that the total IgE was influenced by the sinus disease. Methods: 55 patients about to undergo endoscopic sinus surgery for chronic rhinosinusitis were enrolled in a prospective clinical study. All patients had preoperative sinus computerized tomography (CT) scans and levels of total serum IgE measured before surgery and 1 year postoperatively. Results: Preoperative total IgE levels showed a significant correlation with the extent of disease on sinus CT (rs = 0.413, p = 0.002). Total serum IgE levels did not show any statistically significant change from the preoperative values when measured 1 year postoperatively (324.25 ± 217.30 ng/ml vs. 326.35 ± 204.50 ng/ml; p = 0.61). Conclusions: The levels of total serum IgE do not change after sinus surgery for chronic rhinosinusitis. IgE levels in chronic rhinosinusitis may reflect a systemic factor in disease pathogenesis, and are probably not related to the amount of local inflammation within the sinuses.

Original languageEnglish (US)
Pages (from-to)146-148
Number of pages3
JournalInternational archives of allergy and immunology
Issue number2
StatePublished - Jan 1 2006



  • Chronic rhinosinusitis
  • Chronic sinusitis
  • Sinus surgery

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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